Results 141 to 150 of about 334,121 (353)

Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity

Virology Journal, 2007
Background Lysogenic mode of life cycle of a temperate bacteriophage is generally maintained by a protein called 'repressor'. Repressor proteins of temperate lambdoid phages bind to a few symmetric operator DNAs in order to regulate their gene expression.
Mandal Nitai C, Das Malabika, Chanda Palas K, Chattoraj Partho, Bandhu Amitava, Ganguly Tridib, Sau Subrata   +6 more
doaj   +1 more source

Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction

, 2017
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response.
Barnes, Stephanie L., Belliveau, Nathan M., Chure, Griffin, Einav, Tal, Lewis, Mitchell, Phillips, Rob, Razo-Mejia, Manuel   +6 more
core  

Sensitivity of Phage Lambda upon Variations of the Gibbs Free Energy [PDF]

arXiv, 2003
We investigate the sensitivity of production rates (activities) of the regulatory proteins CI (repressor) and Cro at the right operator (O_R}) of bacteriophage lambda. The DNA binding energies of CI, Cro, and RNA polymerase are perturbed to check the uncertainty of the activity, due to the experimental error, by means of a computational scattering ...
arxiv  

Methylenetetrahydrofolate Dehydrogenase of the Amethopterin-resistant Strain Streptococcus faecium var. durans A _k and Its Repressibility by Serine [PDF]

, 1968
A Albrecht, Franklin K. Pearce, Dorris J. Hutchison   +2 more
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

eLife, 2014
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor ...
James C McGann, Jon A Oyer, Saurabh Garg, Huilan Yao, Jun Liu, Xin Feng, Lujian Liao, John R Yates III, Gail Mandel   +8 more
doaj   +1 more source

Compositionality, stochasticity and cooperativity in dynamic models of gene regulation

, 2007
We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a ``gene gate'' and defines an input/output-relationship corresponding to the binding and ...
Alberts B, Andrew Phillips, Blossey R, Bundschuh R, Cherry JL, De Jong H, Fall CP, Freidlin MI, Kim J, Lee Deville RE, Luca Cardelli, Milner R, Müller S, Phillips A, Priami C, Ralf Blossey, Smolen P, Thomas R, Thomas R, Van Kampen NG   +19 more
core   +2 more sources

Biofilm Control by Active Topography with Mucin Coating

Advanced Functional Materials, EarlyView.
This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han, Yikang Xu, Huan Gu, Teng Zhang, Dacheng Ren   +4 more
wiley   +1 more source

Kinetic approaches to lactose operon induction and bimodality

, 2013
The quasi-equilibrium approximation is acceptable when molecular interactions are fast enough compared to circuit dynamics, but is no longer allowed when cellular activities are governed by rare events.
Michel, Denis
core   +3 more sources

EFFECT OF THE LAMBDA REPRESSOR ON THE BINDING OF RNA POLYMERASE TO DNA [PDF]

, 1969
W S Hayward, Melvin H. Green
openalex   +1 more source