Results 201 to 210 of about 483,350 (345)

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution. [PDF]

Sci Adv
Said-Ahmad A, Shimron N, Samach EF, Naik S, Roy S, Frankel N, Noon EP.   +6 more
europepmc   +1 more source

Kaiso is a genome-wide repressor of transcription that is essential for amphibian development [PDF]

, 2004
Dunican, Donncha S, Meehan, Richard R, Pennings, Sari, Prokhortchouk, Anna, Prokhortchouk, Egor, Ruzov, Alexey, Stancheva, Irina   +6 more
core   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

Balancing nature and technology: enhancing flowering in ornamental plants. [PDF]

Bot Stud
Cai ZR, Sukma D, Chan MT.
europepmc   +1 more source

ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.

Cell, 2002
Z. Gong, T. Morales-Ruiz, R. R. Ariza, T. Roldán-Arjona, Lisa David, Jian-Kang Zhu   +5 more
semanticscholar   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

Molecular Endocrinology, 1993
Elisabetta, Vegeto, Manouchehr, M. M. Shahbaz, Dawn, X. Wen, Mark, E. Goldman, Bert, W. O’Malley, Donald, P. McDonnell   +11 more
semanticscholar   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins. [PDF]

Proc Natl Acad Sci U S A
Klimek A, Dalton BA, Tepper L, Netz RR.
europepmc   +1 more source