Results 221 to 230 of about 483,350 (345)

Engineering plasmids with synthetic origins of replication. [PDF]

Nat Commun
Liu B, Seet ZRD, Peng X, Bennett MR, Lakin MR, Chappell J.   +5 more
europepmc   +1 more source

A repressor complex governs the integration of flowering signals in Arabidopsis.

Developmental Cell, 2008
Dan Li, Chang Liu, Lisha Shen, Yang Wu, Hongyan Chen, M. Robertson, C. Helliwell, Toshiro Ito, E. Meyerowitz, Hao Yu   +9 more
semanticscholar   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD. [PDF]

Brain
Lagartos-Donate MJ, Escobar-Doncel B, Zhang SQ, Pan JP, Villaseca González N, Anisimov A, Montaldo NP, Jensen V, Mao L, Li B, Banzon-Pereira N, Shi L, Cao SQ, Caponio D, Wang P, Nair RR, Luo OJ, Chen G, Nevado-Holgado AJ, Buckley N, Nilsen HL, Fang EF.   +21 more
europepmc   +1 more source

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

Development, 2005
Aimin Liu, Baolin Wang, L. Niswander
semanticscholar   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Enhanced Epigenetic Modulation via mRNA-Encapsulated Lipid Nanoparticles Enables Targeted Anti-inflammatory Control. [PDF]

ACS Synth Biol
Mokhtari T, Taheri MN, Akhlaghi S, Aryannejad A, Xiang Y, Mahajan V, Keshavarz K, Kiani A, Yang S, LoPresti S, LeGraw R, Whitehead KA, Kiani S.   +12 more
europepmc   +1 more source

Role of an Arabidopsis AP2/EREBP-Type Transcriptional Repressor in Abscisic Acid and Drought Stress Responses

The Plant Cell Online, 2005
Chunpeng Song, Manu Agarwal, Masaru Ohta, Yan Guo, U. Halfter, Pengcheng Wang, Jian‐Kang Zhu   +6 more
semanticscholar   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source