Results 241 to 250 of about 264,694 (307)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

Time-delayed activator-repressor regulation of ginsenoside biosynthesis in Gynostemma pentaphyllum. [PDF]

open access: yesNew Phytol
Huang L   +11 more
europepmc   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

open access: yesAdvanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao   +15 more
wiley   +1 more source

Fine-tuned GPT-based foundation models effectively reconstruct bacterial transcriptional regulatory networks from literature. [PDF]

open access: yesFront Artif Intell
Romero-Vilchis J   +5 more
europepmc   +1 more source

Research Advances on the Functions of Transcriptional Regulators in Filamentous Fungi. [PDF]

open access: yesMicroorganisms
Su J   +6 more
europepmc   +1 more source

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