Results 261 to 270 of about 246,170 (311)

Co‐repressors 2000

The FASEB Journal, 2000
ABSTRACT In the last 5 years, many co‐repressors have been identified in eukaryotes that function in a wide range of species, from yeast to Drosophila and humans. Co‐repressors are coregulators that are recruited by DNA‐bound transcriptional silencers and play essential ...
Burke, Les J., Baniahmad, Aria
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Studies of a thermolabile repressor

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965
Abstract From physiological and genetic evidence, it is concluded that the repressor for β-galactosidase (EC 3.2.1.23) synthesis in a mutant bacterium, E-103, is thermolabile. The apparent inactivation of repressor is first order and irreversible; however, paradoxically, only a characteristic fraction can be inactivated at a given temperature ...
T, Horiuchi, A, Novick
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A mechanism for repressor action

Journal of Molecular Biology, 1969
Abstract Deletion mutants have been isolated in which the three structural genes of the lac operon, z , y and a , and the lac operator are fused to the trp operon. In most of these strains, the rate of lac operon expression is greatly increased by the derepression of the trp operon.
W S, Reznikoff, J H, Miller, J G, Scaife, J R, Beckwith   +3 more
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Translational repressors in Drosophila

Trends in Genetics, 2002
Translational regulation is an important aspect of gene regulation, particularly during early development of the fruit fly embryo when transcriptional mechanisms are untenable. Study of pattern formation and dosage compensation has identified several repressors that bind discrete sites in the untranslated portions of target mRNAs.
Kellie A, Dean, Aneel K, Aggarwal, Robin P, Wharton   +2 more
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Toti“potent” repressors

BioEssays, 2006
AbstractA fascinating property of germ cells is their ability to maintain totipotency throughout development. At fertilization, this totipotency is unleashed and the egg generates all the cell types needed to make a brand new organism. Occasionally, germ cells differentiate precociously in the embryo or in the gonads and form teratomas, tumors ...
Christopher M, Gallo, Geraldine, Seydoux
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Crystallization of the Arc repressor

Journal of Molecular Biology, 1985
Arc, a repressor from Salmonella phage P22 has been crystallized from ammonium phosphate at pH 8.0. The crystals form in space group P212121 with a = 90.26 A, b = 52.88 A and c = 47.58 A. The crystals diffract to 2.2 A resolution.
S R, Jordan, C O, Pabo, A K, Vershon, R T, Sauer   +3 more
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Interaction of effecting ligands with lac repressor and repressor-operator complex

Biochemistry, 1975
The equilibrium association constants for the binding of a wide variety of effecting ligands of the lac repressor were measured by equilibrium dialysis. Also, detailed investigations of the apparent rate of dissociation of repressor-operator comples as a function of ligand concentration were carried out for several inducers and anti-inducers.
M D, Barkley, A D, Riggs, A, Jobe, S, Burgeois   +3 more
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Repressors of healthy ageing

Nature Reviews Genetics, 2020
RNA interference screening in Caenorhabditis elegans has identified two repressive epigenetic regulators of age-related behavioural performance that are conserved in mammals.
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Construction of A Dimeric Repressor: Dissection of Subunit Interfaces in Lac Repressor

Biochemistry, 1994
Formation of the lactose repressor tetramer is postulated to involve two subunit interfaces, one primarily contributing to monomer-monomer assembly to dimer and the second to dimer-dimer association to tetramer. The latter interface requires a heptad repeat of three leucines at the C-terminus of lac repressor that is presumed to form an abbreviated ...
J, Chen, R, Surendran, J C, Lee, K S, Matthews   +3 more
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Beyond the Balance of Activator and Repressor

Science Signaling, 2011
Transcription factor binding site affinity has a counterintuitive effect on the regulation of gene expression in response to Hedgehog.
Jolma Arttu, Taipale Jussi, Jolma Arttu, Taipale Jussi   +3 more
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