Results 271 to 280 of about 355,752 (283)

Insights on the effect of macromolecular crowding on transcription and its regulation. [PDF]

QRB Discov
Xu W, Collette D, Qian J, Finzi L, Dunlap D.   +4 more
europepmc   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

CRISPRi-mediated repression of three <i>cI</i> repressors induces the expression of three related <i>Neisseria gonorrhoeae</i> bacteriophages. [PDF]

J Bacteriol
Geslewitz WE, Seifert HS.
europepmc   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Saraswat M, Rueda-Gensini L, Heinzelmann E, Gracia T, Memi F, de Jong G, Straub J, Schloo C, Hoffmann DC, Jung E, Kindinger T, Weigel B, Lim B, Weil S, Gould O, Mair R, Mikulik K, Rohbeck M, Wick W, Winkler F, Bayraktar OA, Stegle O, Mall M.   +22 more
europepmc   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia. [PDF]

Emerg Infect Dis
Zimenkov D, Ushtanit A, Gordeeva E, Guselnikova E, Schwartz Y, Stavitskaya N.   +5 more
europepmc   +1 more source

A 'through-DNA' mechanism for co-regulation of metal uptake and efflux. [PDF]

Nat Commun
Chakraborty UK, Park Y, Sengupta K, Jung W, Joshi CP, Francis DH, Chen P.   +6 more
europepmc   +1 more source

Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae. [PDF]

PLoS One
Nasralddin NA, Haeili M, Karimzadeh S, Alsahlani F.   +3 more
europepmc   +1 more source

Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress. [PDF]

Cell Commun Signal
Spiridon-Bodi M, Ros-Carrero C, Igual JC, Gomar-Alba M.   +3 more
europepmc   +1 more source