Results 271 to 280 of about 382,695 (354)

Heterologous repressor-operator recognition among four classes of tetracycline resistance determinants

, 1985
Gerd Klöck, B. Unger, Christiane Gatz, Wolfgang Hillen, Josef Altenbuchner, Kurt Werner Schmid, R. Schmitt   +6 more
openalex   +1 more source

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury

Advanced Science, EarlyView.
The present study uncovers a novel role of constitutive androstane receptor (CAR) in inflammation‐mediated damage. CAR activation in macrophages inhibits proinflammatory macrophages by interacting with Tlr4, which protects against endotoxemic liver injury.
Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang   +12 more
wiley   +1 more source

c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR. [PDF]

mBio
Mao L, Li J, Huo X, Yang W, Zhang H, Duan C, Shen X, Zhang L.   +7 more
europepmc   +1 more source

A “Mesoporous Oxygen Chamber” Scaffold with Antibacterial and Early Immunomodulatory Effect for Promoting Bone Regeneration

Advanced Science, EarlyView.
In this study, an oxygen‐loaded and antimicrobial peptide (AP)‐functionalized scaffold (MBGAPO) is synthesized. With mesoporous structure of MBG applied as an “oxygen storage,” and AP‐provided antibacterial ability against E.coli and MRSA. MBGAPO exhibited osteogenic and multiplex‐immunomodulatory effects.
You Fu, Dan Lin, Zhicen Lu, Jian Wang, Jing Zhao, Zhiyuan Zhang, Bing Fang, Xiao Yang   +7 more
wiley   +1 more source

Phosphate sensing by PhoPR regulates the cytotoxicity of <i>Staphylococcus aureus</i>. [PDF]

Microbiology (Reading)
Palk N, Brignoli T, Boura M, Massey RC.
europepmc   +1 more source

Interaction of BlaI, the repressor for the β‐lactamase gene of Bacillus licheniformis, with the blaP and blaI promoters

, 1989
Matthew J. Grossman, Ivan H.A. Curran, J. O. Lampen   +2 more
openalex   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Transcriptional regulation as a dose-dependent process: insights from transcription factor tuning. [PDF]

Open Biol
Noviello G.
europepmc   +1 more source

A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate

Advanced Science, EarlyView.
Here, a genetically encoded glutarate biosensor, Glusor, is developed based on transcriptional regulator CsiR. Glusor can quantify glutarate concentrations with good accuracy and precision. Then, the role of KgtP and YnfM are identified and characterized by using Glusor. Glusor also allows glutarate spatiotemporal resolution in live cells, facilitating
Kaiyu Gao, Hui Zhang, Yidong Liu, Xianzhi Xu, Wei Liu, Zhaoqi Kang, Rong Xu, Shuang Hou, Ping Han, Chuanjuan Lü, Cuiqing Ma, Ping Xu, Chao Gao   +12 more
wiley   +1 more source