Insights on the effect of macromolecular crowding on transcription and its regulation. [PDF]
Xu W+4 more
europepmc +1 more source
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu+7 more
wiley +1 more source
CRISPRi-mediated repression of three <i>cI</i> repressors induces the expression of three related <i>Neisseria gonorrhoeae</i> bacteriophages. [PDF]
Geslewitz WE, Seifert HS.
europepmc +1 more source
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li+8 more
wiley +1 more source
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang+10 more
wiley +1 more source
High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia. [PDF]
Zimenkov D+5 more
europepmc +1 more source
A 'through-DNA' mechanism for co-regulation of metal uptake and efflux. [PDF]
Chakraborty UK+6 more
europepmc +1 more source
Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae. [PDF]
Nasralddin NA+3 more
europepmc +1 more source
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress. [PDF]
Spiridon-Bodi M+3 more
europepmc +1 more source