Genes regulated by the
BMC Microbiology, 2010 Background Phenotypic heterogeneity may ensure that a small fraction of a population survives environmental perturbations or may result in lysis in a subpopulation, to increase the survival of siblings.
Gillor Osnat +3 more
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Identification of EppR, a Second Repressor of Error-Prone DNA Polymerase Genes in Acinetobacter baumannii. [PDF]
Mol MicrobiolA novel TetR‐like regulator (EppR) has been identified to repress genes encoding DNA polymerase V in Acinetobacter baumannii through the direct binding of a conserved EppR motif in their promoters. EppR works with previously identified regulator UmuDAb to serve as co‐regulators of these genes. In response to DNA damage and/or environmental stress, both
Nguyen B +6 more
europepmc +2 more sources
Conservation of the LexA repressor binding site in Deinococcus radiodurans [PDF]
Journal of Integrative Bioinformatics, 2008 The LexA protein is a transcriptional repressor of the bacterial SOS DNA repair system, which comprises a set of DNA repair and cellular survival genes that are induced in response to DNA damage.
Khan Feroz, Singh S. P., Mishra B. N.
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LexA, an SOS response repressor, activates TGase synthesis in Streptomyces mobaraensis [PDF]
Frontiers in MicrobiologyTransglutaminase (EC 2.3.2.13, TGase), an enzyme that catalyzes the formation of covalent cross-links between protein or peptide molecules, plays a critical role in commercial food processing, medicine, and textiles.
Xinyu Shi +11 more
doaj +2 more sources
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons [PDF]
Mobile DNA, 2011 Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume +9 more
doaj +12 more sources
Staphylococcus aureus SOS response: Activation, impact, and drug targets. [PDF]
mLifeAbstract Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and small colony variants.
Cheng K +5 more
europepmc +2 more sources
Fluorescence study of the RecA‐dependent proteolysis of LexA, the represser of the SOS system in Escherichia coli [PDF]
, 1986 The fluorescence of the LexA protein, the common repressor of the SOS system in Escherichia coli decreases by about 30% upon incubation with the Ree A protein, and its cofactors ATP [or its non-hydroly sable analogue adenosine-5'-O-(3-thiotriphosphate ...
Masayuki Takahashi +2 more
openalex +3 more sources
A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus. [PDF]
PLoS Biology, 2014 Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA ...
Joshua W Modell +3 more
doaj +6 more sources
Global analysis of the regulon of the transcriptional repressor LexA, a key component of SOS response in Mycobacterium tuberculosis. [PDF]
J Biol Chem, 2012 Smollett KL +5 more
europepmc +3 more sources
UmuDAb: An Error-Prone Polymerase Accessory Homolog Whose N-Terminal Domain Is Required for Repression of DNA Damage Inducible Gene Expression in Acinetobacter baylyi. [PDF]
PLoS ONE, 2016 In many bacteria, the DNA damage response induces genes (SOS genes) that were repressed by LexA. LexA represses transcription by binding to SOS promoters via a helix-turn-helix motif in its N-terminal domain (NTD).
Travis A Witkowski +5 more
doaj +1 more source