Genes regulated by the
BMC Microbiology, 2010 Background Phenotypic heterogeneity may ensure that a small fraction of a population survives environmental perturbations or may result in lysis in a subpopulation, to increase the survival of siblings.
Gillor Osnat +3 more
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Conservation of the LexA repressor binding site in Deinococcus radiodurans [PDF]
Journal of Integrative Bioinformatics, 2008 The LexA protein is a transcriptional repressor of the bacterial SOS DNA repair system, which comprises a set of DNA repair and cellular survival genes that are induced in response to DNA damage.
Khan Feroz, Singh S. P., Mishra B. N.
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LexA, an SOS response repressor, activates TGase synthesis in Streptomyces mobaraensis [PDF]
Frontiers in MicrobiologyTransglutaminase (EC 2.3.2.13, TGase), an enzyme that catalyzes the formation of covalent cross-links between protein or peptide molecules, plays a critical role in commercial food processing, medicine, and textiles.
Xinyu Shi +11 more
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Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons [PDF]
Mobile DNA, 2011 Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume +9 more
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Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction. [PDF]
PLoS BiologyBacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a temporally structured manner.
Aditya Kamat +3 more
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Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida [PDF]
Current Research in Microbial SciencesLexA is a well-known transcriptional repressor of DNA repair genes induced by DNA damage in Escherichia coli and other bacterial species. Recently, this paradigm—that LexA solely regulates the SOS response—has been challenged as studies reveal its ...
Rongchao He +4 more
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Sensing Cellular Damages Induced by Food Safety Hazards Using Bacterial Stress-Responsive Biosensors [PDF]
BiosensorsFood safety hazards induce diverse cellular damages including DNA damage, oxidative stress, proteotoxic stress, and membrane disruption, ultimately contributing to various human diseases.
Ruiqi Li, Manzhuan Lou, Wei He, Shu Quan
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A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus. [PDF]
PLoS Biology, 2014 Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA ...
Joshua W Modell +3 more
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DdiA, an XRE family transcriptional regulator, is a co-regulator of the DNA damage response in Myxococcus xanthus [PDF]
Journal of BacteriologyRepair of DNA damage is essential for genome integrity. DNA damage elicits a DNA damage response (DDR) that includes error-free and error-prone, i.e., mutagenic, repair. The SOS response is a widely conserved system in bacteria that regulates the DDR and
Jana Jung +3 more
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Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis [PDF]
iScienceSummary: Antimicrobial resistance poses a severe threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency.
Filippo Vascon +11 more
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