Results 1 to 10 of about 122,043 (148)
Quinolone Resistance Reversion by Targeting the SOS Response
mBio, 2017 Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli ...
E. Recacha +8 more
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Computational analysis of LexA regulons in Cyanobacteria [PDF]
BMC Genomics, 2010 Background The transcription factor LexA plays an important role in the SOS response in Escherichia coli and many other bacterial species studied.
Su Zhengchang, Xu Minli, Li Shan
doaj +3 more sources
Frontiers in Microbiology, 2020 Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance ...
Zdravko Podlesek, Darja Žgur Bertok
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Bacteria under SOS evolve anticancer phenotypes [PDF]
Infectious Agents and Cancer, 2010 Background The anticancer drugs, such as DNA replication inhibitors, stimulate bacterial adhesion and induce the bacterial SOS response. As a variety of bacterial mutants can be generated during SOS, novel phenotypes are likely to be selected under the ...
Weitao Tao, Dallo Shatha F
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Ribonuclease E modulation of the bacterial SOS response. [PDF]
PLoS ONE, 2012 Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction
Robert Manasherob +3 more
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Structural basis for regulation of SOS response in bacteria
Proceedings of the National Academy of Sciences of the United States of America, 2023 In response to DNA damage, bacterial RecA protein forms filaments with the assistance of DinI protein. The RecA filaments stimulate the autocleavage of LexA, the repressor of more than 50 SOS genes, and activate the SOS response. During the late phase of SOS response, the RecA filaments stimulate the autocleavage of UmuD and λ repressor CI,
Liang Liang, Aijia Wen, Chun Zhou
exaly +3 more sources
Frontiers in Microbiology, 2018 Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood +12 more
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Frontiers in MicrobiologyBacteria have evolved numerous regulatory pathways to survive in changing environments. The SOS response is an inducible DNA damage repair system that plays an indispensable role in bacterial adaptation and pathogenesis. Here we report a discovery of the
Magdalena Ładziak +10 more
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Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. [PDF]
PLoS ONE, 2017 Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E.
Bryan E Bunnell +4 more
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Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]
PLoS ONE, 2008 Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long +3 more
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