Quinolone Resistance Reversion by Targeting the SOS Response
mBio, 2017 Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli ...
E. Recacha +8 more
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Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli [PDF]
Microbiology SpectrumThe SOS response is a critical DNA damage repair mechanism in bacteria, designed to counteract genotoxic stress and ensure survival. This system can be activated by different classes of antimicrobial agents, each inducing the SOS response through ...
Ruoxuan Zhao +5 more
doaj +2 more sources
Genome-Wide Identification and Expression Analysis of SOS Response Genes in Salmonella enterica Serovar Typhimurium [PDF]
Cells, 2021 A bioinformatic search for LexA boxes, combined with transcriptomic detection of loci responsive to DNA damage, identified 48 members of the SOS regulon in the genome of Salmonella enterica serovar Typhimurium.
Angela Mérida-Floriano +2 more
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Inhibition of SOS Response by Nitric Oxide Donors in Escherichia coli Blocks Toxin Production and Hypermutation [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 BackgroundPrevious reports have differed as to whether nitric oxide inhibits or stimulates the SOS response, a bacterial stress response that is often triggered by DNA damage. The SOS response is an important regulator of production of Shiga toxins (Stx)
John K. Crane +2 more
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Inactivation of lmo0946 (sif) induces the SOS response and MGEs mobilization and silences the general stress response and virulence program in Listeria monocytogenes [PDF]
Frontiers in Microbiology, 2023 Bacteria have evolved numerous regulatory pathways to survive in changing environments. The SOS response is an inducible DNA damage repair system that plays an indispensable role in bacterial adaptation and pathogenesis. Here we report a discovery of the
Magdalena Ładziak +10 more
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The effect of hyper-induced SOS response on evolution in Escherichia coli [PDF]
BMC MicrobiologyBackground The SOS response, a conserved bacterial DNA repair system, plays a critical role in adaptation under stress, by inducing spontaneous mutations.
Ruoxuan Zhao +4 more
doaj +2 more sources
The Role of the SOS Response in the Adaptation of Pseudomonas aeruginosa [PDF]
Current Issues in Molecular BiologyPseudomonas aeruginosa is a major opportunistic pathogen whose adaptive capacity limits the long-term efficacy of antibiotic therapy. Beyond classical resistance mechanisms, antibiotics may also act as stress signals that alter bacterial physiology and ...
Emilia Zarembska +2 more
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Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction. [PDF]
PLoS BiologyBacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a temporally structured manner.
Aditya Kamat +3 more
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Staphylococcus aureus SOS response: Activation, impact, and drug targets [PDF]
mLifeStaphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and ...
Kaiying Cheng +5 more
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Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against Escherichia coli [PDF]
Frontiers in MicrobiologyIntroductionTargeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials.
Marina Murillo-Torres +14 more
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