Structural basis for regulation of SOS response in bacteria. [PDF]
Proc Natl Acad Sci U S A, 2023 In response to DNA damage, bacterial RecA protein forms filaments with the assistance of DinI protein. The RecA filaments stimulate the autocleavage of LexA, the repressor of more than 50 SOS genes, and activate the SOS response. During the late phase of SOS response, the RecA filaments stimulate the autocleavage of UmuD and λ repressor CI,
Gao B +5 more
europepmc +4 more sources
The DNA Damage Inducible SOS Response Is a Key Player in the Generation of Bacterial Persister Cells and Population Wide Tolerance [PDF]
Frontiers in Microbiology, 2020 Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance ...
Zdravko Podlesek, Darja Žgur Bertok
doaj +4 more sources
Inactivation of lmo0946 (sif) induces the SOS response and MGEs mobilization and silences the general stress response and virulence program in Listeria monocytogenes [PDF]
Frontiers in Microbiology, 2023 Bacteria have evolved numerous regulatory pathways to survive in changing environments. The SOS response is an inducible DNA damage repair system that plays an indispensable role in bacterial adaptation and pathogenesis. Here we report a discovery of the
Magdalena Ładziak +10 more
doaj +4 more sources
Quinolone Resistance Reversion by Targeting the SOS Response
mBio, 2017 Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli ...
E. Recacha +8 more
doaj +9 more sources
Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli [PDF]
Microbiology SpectrumThe SOS response is a critical DNA damage repair mechanism in bacteria, designed to counteract genotoxic stress and ensure survival. This system can be activated by different classes of antimicrobial agents, each inducing the SOS response through ...
Ruoxuan Zhao +5 more
doaj +2 more sources
Genome-Wide Identification and Expression Analysis of SOS Response Genes in Salmonella enterica Serovar Typhimurium [PDF]
Cells, 2021 A bioinformatic search for LexA boxes, combined with transcriptomic detection of loci responsive to DNA damage, identified 48 members of the SOS regulon in the genome of Salmonella enterica serovar Typhimurium.
Angela Mérida-Floriano +2 more
doaj +2 more sources
Inhibition of SOS Response by Nitric Oxide Donors in Escherichia coli Blocks Toxin Production and Hypermutation [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 BackgroundPrevious reports have differed as to whether nitric oxide inhibits or stimulates the SOS response, a bacterial stress response that is often triggered by DNA damage. The SOS response is an important regulator of production of Shiga toxins (Stx)
John K. Crane +2 more
doaj +2 more sources
The effect of hyper-induced SOS response on evolution in Escherichia coli [PDF]
BMC MicrobiologyBackground The SOS response, a conserved bacterial DNA repair system, plays a critical role in adaptation under stress, by inducing spontaneous mutations.
Ruoxuan Zhao +4 more
doaj +2 more sources
Ribonuclease E modulation of the bacterial SOS response. [PDF]
PLoS ONE, 2012 Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction
Robert Manasherob +3 more
doaj +3 more sources
Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction. [PDF]
PLoS BiologyBacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a temporally structured manner.
Aditya Kamat +3 more
doaj +2 more sources