Results 31 to 40 of about 30,449 (250)

Predrought and Its Persistence Determined the Phenological Changes of Stipa krylovii in Inner Mongolia

Agronomy, 2023
Clarifying the response of plant phenology to drought duration is helpful for accurately interpreting and predicting carbon sinks in ecosystems. Based on the response of different phenological periods of the dominant species Stipa krylovii to monthly ...
Erhua Liu, Guangsheng Zhou, Qijin He, Bingyi Wu, Xiaomin Lv   +4 more
doaj   +1 more source

Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]

PLoS ONE, 2010
The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
doaj   +1 more source

RecA and Specialized Error-Prone DNA Polymerases Are Not Required for Mutagenesis and Antibiotic Resistance Induced by Fluoroquinolones in Pseudomonas aeruginosa

Antibiotics, 2022
To cope with stressful conditions, including antibiotic exposure, bacteria activate the SOS response, a pathway that induces error-prone DNA repair and mutagenesis mechanisms.
Jessica Mercolino, Alessandra Lo Sciuto, Maria Concetta Spinnato, Giordano Rampioni, Francesco Imperi   +4 more
doaj   +1 more source

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Frontiers in Microbiology
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum, Amanda Holstad Singleton, Lisa Marie Røst, Antoine Bodein, Marie-Pier Scott-Boyer, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Arnaud Droit, Per Bruheim, Marit Otterlei, Marit Otterlei   +12 more
doaj   +1 more source

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Frontiers in Microbiology, 2018
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood, Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Charlie Y. Mo, Matthew J. Culyba, Matthew J. Culyba, Zachary M. Hostetler, Zachary M. Hostetler, Rahul M. Kohli, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh   +12 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Activation and modulation of the host response to DNA damage by an integrative and conjugative element

Journal of Bacteriology
Mobile genetic elements help drive horizontal gene transfer and bacterial evolution. Conjugative elements and temperate bacteriophages can be stably maintained in host cells.
Saria McKeithen-Mead, Mary E. Anderson, Alam García-Heredia, Alan D. Grossman   +3 more
doaj   +1 more source

Role of RecA and the SOS response in thymineless death in Escherichia coli. [PDF]

PLoS Genetics, 2010
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine.
Natalie C Fonville, David Bates, P J Hastings, Philip C Hanawalt, Susan M Rosenberg   +4 more
doaj   +1 more source

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

eLife, 2022
The plasmid-mediated quinolone resistance (PMQR) genes have been shown to promote high-level bacterial resistance to fluoroquinolone antibiotics, potentially leading to clinical treatment failures.
Anamaria Babosan, David Skurnik, Anaëlle Muggeo, Gerald B Pier, Zeynep Baharoglu, Thomas Jové, Marie-Cécile Ploy, Sophie Griveau, Fethi Bedioui, Sébastien Vergnolle, Sophie Moussalih, Christophe de Champs, Didier Mazel, Thomas Guillard   +13 more
doaj   +1 more source