Results 31 to 40 of about 29,104 (247)

Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. [PDF]

PLoS Biology, 2005
The SOS genetic network is responsible for the repair/bypass of DNA damage in bacterial cells. While the initial stages of the response have been well characterized, less is known about the dynamics of the response after induction and its shutoff.
Nir Friedman, Shuki Vardi, Michal Ronen, Uri Alon, Joel Stavans   +4 more
doaj   +2 more sources

Role of Extracellular DNA in Bacterial Response to SOS-Inducing Drugs

Antibiotics, 2023
The SOS response is a conserved stress response pathway that is triggered by DNA damage in the bacterial cell. Activation of this pathway can, in turn, cause the rapid appearance of new mutations, sometimes called hypermutation.
John K. Crane, Marissa N. Catanzaro
doaj   +1 more source

Predrought and Its Persistence Determined the Phenological Changes of Stipa krylovii in Inner Mongolia

Agronomy, 2023
Clarifying the response of plant phenology to drought duration is helpful for accurately interpreting and predicting carbon sinks in ecosystems. Based on the response of different phenological periods of the dominant species Stipa krylovii to monthly ...
Erhua Liu, Guangsheng Zhou, Qijin He, Bingyi Wu, Xiaomin Lv   +4 more
doaj   +1 more source

SOS-Inducing Drugs Trigger Nucleic Acid Release and Biofilm Formation in Gram-Negative Bacteria

Biomolecules
Our laboratory recently reported that induction of the SOS response, triggered by SOS-inducing drugs, was accompanied by a large release of DNA from enteric bacteria.
Peter Demjanenko, Sam Zheng, John K. Crane   +2 more
doaj   +1 more source

Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]

PLoS ONE, 2010
The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
doaj   +1 more source

RecA and Specialized Error-Prone DNA Polymerases Are Not Required for Mutagenesis and Antibiotic Resistance Induced by Fluoroquinolones in Pseudomonas aeruginosa

Antibiotics, 2022
To cope with stressful conditions, including antibiotic exposure, bacteria activate the SOS response, a pathway that induces error-prone DNA repair and mutagenesis mechanisms.
Jessica Mercolino, Alessandra Lo Sciuto, Maria Concetta Spinnato, Giordano Rampioni, Francesco Imperi   +4 more
doaj   +1 more source

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Frontiers in Microbiology
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum, Amanda Holstad Singleton, Lisa Marie Røst, Antoine Bodein, Marie-Pier Scott-Boyer, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Arnaud Droit, Per Bruheim, Marit Otterlei, Marit Otterlei   +12 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Skin‐Like Strain Sensor for Real‐Time Human Motion Detection

Advanced Functional Materials, EarlyView.
A skin‐like strain sensor with exceptional flexibility and breathability enables real‐time human motion detection. It offers continuous ECG monitoring and gesture recognition, ensuring high durability and comfort. This innovative design is ideal for wearable applications, combining reliable performance with seamless integration into dynamic ...
Shiqi Song, Zhe Li, Jingya Guo, Shuo Shi, Jian Fang, Xungai Wang   +5 more
wiley   +1 more source