Results 31 to 40 of about 29,159 (246)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Role of Extracellular DNA in Bacterial Response to SOS-Inducing Drugs

Antibiotics, 2023
The SOS response is a conserved stress response pathway that is triggered by DNA damage in the bacterial cell. Activation of this pathway can, in turn, cause the rapid appearance of new mutations, sometimes called hypermutation.
John K. Crane, Marissa N. Catanzaro
doaj   +1 more source

Predrought and Its Persistence Determined the Phenological Changes of Stipa krylovii in Inner Mongolia

Agronomy, 2023
Clarifying the response of plant phenology to drought duration is helpful for accurately interpreting and predicting carbon sinks in ecosystems. Based on the response of different phenological periods of the dominant species Stipa krylovii to monthly ...
Erhua Liu, Guangsheng Zhou, Qijin He, Bingyi Wu, Xiaomin Lv   +4 more
doaj   +1 more source

SOS-Inducing Drugs Trigger Nucleic Acid Release and Biofilm Formation in Gram-Negative Bacteria

Biomolecules
Our laboratory recently reported that induction of the SOS response, triggered by SOS-inducing drugs, was accompanied by a large release of DNA from enteric bacteria.
Peter Demjanenko, Sam Zheng, John K. Crane   +2 more
doaj   +1 more source

Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]

PLoS ONE, 2010
The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
doaj   +1 more source

RecA and Specialized Error-Prone DNA Polymerases Are Not Required for Mutagenesis and Antibiotic Resistance Induced by Fluoroquinolones in Pseudomonas aeruginosa

Antibiotics, 2022
To cope with stressful conditions, including antibiotic exposure, bacteria activate the SOS response, a pathway that induces error-prone DNA repair and mutagenesis mechanisms.
Jessica Mercolino, Alessandra Lo Sciuto, Maria Concetta Spinnato, Giordano Rampioni, Francesco Imperi   +4 more
doaj   +1 more source

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Frontiers in Microbiology
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum, Amanda Holstad Singleton, Lisa Marie Røst, Antoine Bodein, Marie-Pier Scott-Boyer, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Arnaud Droit, Per Bruheim, Marit Otterlei, Marit Otterlei   +12 more
doaj   +1 more source

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Frontiers in Microbiology, 2018
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood, Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Charlie Y. Mo, Matthew J. Culyba, Matthew J. Culyba, Zachary M. Hostetler, Zachary M. Hostetler, Rahul M. Kohli, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh   +12 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Role of RecA and the SOS response in thymineless death in Escherichia coli. [PDF]

PLoS Genetics, 2010
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine.
Natalie C Fonville, David Bates, P J Hastings, Philip C Hanawalt, Susan M Rosenberg   +4 more
doaj   +1 more source