Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli [PDF]
Microbiology SpectrumThe SOS response is a critical DNA damage repair mechanism in bacteria, designed to counteract genotoxic stress and ensure survival. This system can be activated by different classes of antimicrobial agents, each inducing the SOS response through ...
Ruoxuan Zhao +5 more
doaj +2 more sources
Inhibition of SOS Response by Nitric Oxide Donors in Escherichia coli Blocks Toxin Production and Hypermutation [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 BackgroundPrevious reports have differed as to whether nitric oxide inhibits or stimulates the SOS response, a bacterial stress response that is often triggered by DNA damage. The SOS response is an important regulator of production of Shiga toxins (Stx)
John K. Crane +2 more
doaj +2 more sources
Genome-Wide Identification and Expression Analysis of SOS Response Genes in Salmonella enterica Serovar Typhimurium [PDF]
Cells, 2021 A bioinformatic search for LexA boxes, combined with transcriptomic detection of loci responsive to DNA damage, identified 48 members of the SOS regulon in the genome of Salmonella enterica serovar Typhimurium.
Angela Mérida-Floriano +2 more
doaj +2 more sources
The effect of hyper-induced SOS response on evolution in Escherichia coli [PDF]
BMC MicrobiologyBackground The SOS response, a conserved bacterial DNA repair system, plays a critical role in adaptation under stress, by inducing spontaneous mutations.
Ruoxuan Zhao +4 more
doaj +2 more sources
Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction. [PDF]
PLoS BiologyBacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a temporally structured manner.
Aditya Kamat +3 more
doaj +2 more sources
Staphylococcus aureus SOS response: Activation, impact, and drug targets [PDF]
mLifeStaphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and ...
Kaiying Cheng +5 more
doaj +2 more sources
The Role of the SOS Response in the Adaptation of Pseudomonas aeruginosa [PDF]
Current Issues in Molecular BiologyPseudomonas aeruginosa is a major opportunistic pathogen whose adaptive capacity limits the long-term efficacy of antibiotic therapy. Beyond classical resistance mechanisms, antibiotics may also act as stress signals that alter bacterial physiology and ...
Emilia Zarembska +2 more
doaj +2 more sources
Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against Escherichia coli [PDF]
Frontiers in MicrobiologyIntroductionTargeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials.
Marina Murillo-Torres +14 more
doaj +2 more sources
Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response [PDF]
BMC MicrobiologyBackground Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge.
Lisa Teichmann +3 more
doaj +2 more sources
The SOS Response of Biofilms [PDF]
International Journal of Clinical & Medical Microbiology, 2016 Background: Biofilms predominate in nearly all nutrient-sufficient ecosystems, both natural and clinical. In clinical settings, bacteria often encounter antimicrobial and DNA damaging agents. Factual evidence shows that more and more biofilm inducing antimicrobials trigger the SOS response of bacteria.
Katie Leiker, Tao Weitao
openaire +1 more source