Results 11 to 20 of about 30,449 (250)

Structural basis for regulation of SOS response in bacteria. [PDF]

Proc Natl Acad Sci U S A, 2023
In response to DNA damage, bacterial RecA protein forms filaments with the assistance of DinI protein. The RecA filaments stimulate the autocleavage of LexA, the repressor of more than 50 SOS genes, and activate the SOS response.
Gao B, Liang L, Su L, Wen A, Zhou C, Feng Y.   +5 more
europepmc   +4 more sources

Ribonuclease E modulation of the bacterial SOS response. [PDF]

PLoS ONE, 2012
Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction
Robert Manasherob, Christine Miller, Kwang-sun Kim, Stanley N Cohen   +3 more
doaj   +3 more sources

Targeting evolution of antibiotic resistance by SOS response inhibition. [PDF]

Comput Struct Biotechnol J, 2021
Yakimov A, Bakhlanova I, Baitin D.
europepmc   +2 more sources

A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response.

Cell Rep, 2022
Azulay G, Pasechnek A, Stadnyuk O, Ran-Sapir S, Fleisacher AM, Borovok I, Sigal N, Herskovits AA.   +7 more
europepmc   +2 more sources

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]

PLoS ONE, 2008
Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long, Nicholas Renzette, Richard C Centore, Steven J Sandler   +3 more
doaj   +1 more source

The SOS Response of Biofilms [PDF]

International Journal of Clinical & Medical Microbiology, 2016
Background: Biofilms predominate in nearly all nutrient-sufficient ecosystems, both natural and clinical. In clinical settings, bacteria often encounter antimicrobial and DNA damaging agents. Factual evidence shows that more and more biofilm inducing antimicrobials trigger the SOS response of bacteria.
Katie Leiker, Tao Weitao
openaire   +1 more source

The DNA Damage Inducible SOS Response Is a Key Player in the Generation of Bacterial Persister Cells and Population Wide Tolerance

Frontiers in Microbiology, 2020
Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance ...
Zdravko Podlesek, Darja Žgur Bertok
doaj   +1 more source

The SOS response regulates adaptive mutation [PDF]

Proceedings of the National Academy of Sciences, 2000
Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment.
G J, McKenzie, R S, Harris, P L, Lee, S M, Rosenberg   +3 more
openaire   +2 more sources

Growth‐dependent heterogeneity in the DNA damage response in Escherichia coli

Molecular Systems Biology, 2022
In natural environments, bacteria are frequently exposed to sub‐lethal levels of DNA damage, which leads to the induction of a stress response (the SOS response in Escherichia coli).
Sebastián Jaramillo‐Riveri, James Broughton, Alexander McVey, Teuta Pilizota, Matthew Scott, Meriem El Karoui   +5 more
doaj   +1 more source

The SOS response is permitted in Escherichia coli strains deficient in the expression of the mazEF pathway. [PDF]

PLoS ONE, 2014
The Escherichia coli (E. coli) SOS response is the largest, most complex, and best characterized bacterial network induced by DNA damage. It is controlled by a complex network involving the RecA and LexA proteins.
Ziva Kalderon, Sathish Kumar, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source