Results 11 to 20 of about 29,104 (247)

Staphylococcus aureus SOS response: Activation, impact, and drug targets [PDF]

mLife
Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and ...
Kaiying Cheng, Yukang Sun, Huan Yu, Yingxuan Hu, Yini He, Yuanyuan Shen   +5 more
doaj   +2 more sources

The Role of the SOS Response in the Adaptation of Pseudomonas aeruginosa [PDF]

Current Issues in Molecular Biology
Pseudomonas aeruginosa is a major opportunistic pathogen whose adaptive capacity limits the long-term efficacy of antibiotic therapy. Beyond classical resistance mechanisms, antibiotics may also act as stress signals that alter bacterial physiology and ...
Emilia Zarembska, Anna Pietruczuk-Padzik, Małgorzata Wrzosek   +2 more
doaj   +2 more sources

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Frontiers in Microbiology, 2018
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood, Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Charlie Y. Mo, Matthew J. Culyba, Matthew J. Culyba, Zachary M. Hostetler, Zachary M. Hostetler, Rahul M. Kohli, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh   +12 more
doaj   +3 more sources

Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against Escherichia coli [PDF]

Frontiers in Microbiology
IntroductionTargeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials.
Marina Murillo-Torres, Marina Murillo-Torres, Isabel María Peñalver-Fernández, Marta Quero-Delgado, Sara Diaz-Diaz, María Romero-Muñoz, Esther Recacha, Esther Recacha, Esther Recacha, Fernando Docobo-Pérez, Fernando Docobo-Pérez, Fernando Docobo-Pérez, José Manuel Rodríguez-Martínez, José Manuel Rodríguez-Martínez, José Manuel Rodríguez-Martínez   +14 more
doaj   +2 more sources

Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response [PDF]

BMC Microbiology
Background Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge.
Lisa Teichmann, Sam Luitwieler, Johan Bengtsson-Palme, Benno ter Kuile   +3 more
doaj   +2 more sources

Targeting evolution of antibiotic resistance by SOS response inhibition. [PDF]

Comput Struct Biotechnol J, 2021
Yakimov A, Bakhlanova I, Baitin D.
europepmc   +2 more sources

A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response.

Cell Rep, 2022
Azulay G, Pasechnek A, Stadnyuk O, Ran-Sapir S, Fleisacher AM, Borovok I, Sigal N, Herskovits AA.   +7 more
europepmc   +2 more sources

Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. [PDF]

PLoS ONE, 2017
Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E.
Bryan E Bunnell, Jillian F Escobar, Kirsten L Bair, Mark D Sutton, John K Crane   +4 more
doaj   +1 more source

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]

PLoS ONE, 2008
Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long, Nicholas Renzette, Richard C Centore, Steven J Sandler   +3 more
doaj   +1 more source

The SOS Response of Biofilms [PDF]

International Journal of Clinical & Medical Microbiology, 2016
Background: Biofilms predominate in nearly all nutrient-sufficient ecosystems, both natural and clinical. In clinical settings, bacteria often encounter antimicrobial and DNA damaging agents. Factual evidence shows that more and more biofilm inducing antimicrobials trigger the SOS response of bacteria.
Katie Leiker, Tao Weitao
openaire   +1 more source