Results 41 to 50 of about 30,449 (250)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tracking Battery Microstructural Degradation Through Directional Thermal Transport Signatures

Advanced Functional Materials, EarlyView.
In lithium‐ion batteries, heat conduction varies between the through‐plane and in‐plane directions because of the cell's layered structure. Therefore, cell degradation influences thermal conductivity in each direction uniquely due to detailed microstructural and compositional changes.
Mohammad Shoghi Tekmedash, Rituparna Mohanty, Jack Leber, David Nageb, Mirella Richard, Sharan Singh, Amin Reihani   +6 more
wiley   +1 more source

DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm

Frontiers in Microbiology
The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control.
Hari Sharan Misra, Yogendra Singh Rajpurohit, Yogendra Singh Rajpurohit   +2 more
doaj   +1 more source

Computational analysis of LexA regulons in Cyanobacteria

BMC Genomics, 2010
Background The transcription factor LexA plays an important role in the SOS response in Escherichia coli and many other bacterial species studied.
Su Zhengchang, Xu Minli, Li Shan
doaj   +1 more source

Comparison of Phenological Parameters Extracted from SIF, NDVI and NIRv Data on the Mongolian Plateau

Remote Sensing, 2022
The phenological parameters estimated from different data may vary, especially in response to climatic factors. Therefore, we estimated the start of the growing season (SOS) and the end of the growing season (EOS) based on sunlight-induced chlorophyll ...
Cha Ersi, Tubuxin Bayaer, Yuhai Bao, Yulong Bao, Mei Yong, Quan Lai, Xiang Zhang, Yusi Zhang   +7 more
doaj   +1 more source

Flexible Pressure Sensor With Co‐Optimized Sensitivity and Linearity Based on Gradient Toroidal Microstructures

Advanced Materials Technologies, EarlyView.
A flexible piezoresistive pressure sensor with gradient toroidal CNT/PDMS microstructures is reported. The hierarchical geometry enables sequential electrode contact, achieving a sensitivity of 256.20 kPa−1 and linear response (R2 = 0.99) over 0–1000 kPa.
Rongmei Wang, Ruolin Liu, Ming Lei, Yifan Liu, Fengming Hu, Bing Ji, Chao Peng, Jianyi Luo, Bingpu Zhou   +8 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae. [PDF]

PLoS Genetics, 2013
Bacteria encounter sub-inhibitory concentrations of antibiotics in various niches, where these low doses play a key role for antibiotic resistance selection.
Zeynep Baharoglu, Evelyne Krin, Didier Mazel   +2 more
doaj   +1 more source

Recent Advances in Light‐Addressable Electrochemistry for Spatially Resolved Applications

Advanced Materials Technologies, EarlyView.
This comprehensive review highlights light‐addressable electrochemistry as a powerful tool that uses light to control localized chemical reactions on unstructured semiconductor surfaces. The work evaluates advanced strategies to optimize electrode materials for enhanced spatial resolution and stability. Furthermore, it showcases diverse applications in
Nhi Trang Vo, Sina Jamali, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

Response to ‘Not-so-simple setae’ [PDF]

Journal of Experimental Biology, 2011
In his Correspondence article ([p. 871][1]), DeForest Mellon, Jr argues that the type of seta in our report ([Monteclaro et al., 2010][2]) was erroneously identified. In response, we would like to make the following remarks.
openaire   +1 more source