Results 41 to 50 of about 149,893 (184)

Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]

PLoS ONE, 2010
The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
doaj   +1 more source

Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase

, 2015
The dnaQ gene of Escherichia coli encodes the Ɛ subunit of DNA polymerase III, which provides the 3\u27 - 5\u27 exonuclease proofreading activity of the replicative polymerase.
Kreuzer, Kenneth N., Whatley, Zakiya
core   +1 more source

SOS-Inducing Drugs Trigger Nucleic Acid Release and Biofilm Formation in Gram-Negative Bacteria

Biomolecules
Our laboratory recently reported that induction of the SOS response, triggered by SOS-inducing drugs, was accompanied by a large release of DNA from enteric bacteria.
Peter Demjanenko, Sam Zheng, John K. Crane   +2 more
doaj   +1 more source

The SOS response of Listeria monocytogenes is involved in stress resistance and mutagenesis [PDF]

The SOS response is a conserved pathway that is activated under certain stress conditions and is regulated by the repressor LexA and the activator RecA.
Abee, T., Molenaar, D., Schalkwijk, S., van, Veen, S., van der, Vos, W.M., de, Wells-Bennik, M.H.J.   +5 more
core   +1 more source

RecA and Specialized Error-Prone DNA Polymerases Are Not Required for Mutagenesis and Antibiotic Resistance Induced by Fluoroquinolones in Pseudomonas aeruginosa

Antibiotics, 2022
To cope with stressful conditions, including antibiotic exposure, bacteria activate the SOS response, a pathway that induces error-prone DNA repair and mutagenesis mechanisms.
Jessica Mercolino, Alessandra Lo Sciuto, Maria Concetta Spinnato, Giordano Rampioni, Francesco Imperi   +4 more
doaj   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Frontiers in Microbiology
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum, Amanda Holstad Singleton, Lisa Marie Røst, Antoine Bodein, Marie-Pier Scott-Boyer, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Arnaud Droit, Per Bruheim, Marit Otterlei, Marit Otterlei   +12 more
doaj   +1 more source

Approaching exact hyperpolarizabilities via sum-over-states Monte Carlo configuration interaction [PDF]

, 2014
We propose using sum-over-states calculations with the compact wavefunctions of Monte Carlo configuration interaction to approach accurate values for higher-order dipole properties up to second hyperpolarizabilities in a controlled way.
Coe, J. P., Paterson, M. J.
core   +2 more sources

Postantibiotic SOS response states in E. coli intestinal microbiocenoses and their possible consequences (review)

Ветеринария и кормление
The study of the effects of stress on E. coli in the intestine, realized through SOS-response reactions, is important for understanding the possible consequences for microbiocenoses.
Afonyushkin V.N., Kilp A.S., Donchenko A.S., Sumarokova A.D.   +3 more
doaj   +1 more source

Role of RecA and the SOS response in thymineless death in Escherichia coli. [PDF]

PLoS Genetics, 2010
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine.
Natalie C Fonville, David Bates, P J Hastings, Philip C Hanawalt, Susan M Rosenberg   +4 more
doaj   +1 more source