Results 101 to 110 of about 115,119 (230)

Characterization of a membrane toxin‐antitoxin system, tsaAT, from Staphylococcus aureus

The FEBS Journal, Volume 291, Issue 22, Page 5015-5036, November 2024.
Bacterial toxin‐antitoxin (TA) systems are comprised of a toxin that inhibits essential cellular functions and its cognate antitoxin that neutralizes the toxicity. Here, we show that Staphylococcus aureus TA system, TsaA/TsaT, uniquely consists of two membrane proteins and the TsaT overexpression disrupts membrane integrity in Escherichia coli and S ...
Fuminori Kato, Risa Bandou, Yoshihiro Yamaguchi, Keiko Inouye, Masayori Inouye   +4 more
wiley   +1 more source

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.

ACS Infectious Diseases, 2018
The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet nontraditional, drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo ...
Charlie Y. Mo, M. Culyba, T. Selwood, J. Kubiak, Z. M. Hostetler, A. Jurewicz, P. Keller, A. Pope, Amy M. Quinn, J. Schneck, K. Widdowson, R. Kohli   +11 more
semanticscholar   +1 more source

Genome Wide Mapping of Peptidases in Rhodnius prolixus: Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae

Frontiers in Physiology, 2017
Triatominae is a subfamily of the order Hemiptera whose species are able to feed in the vertebrate blood (i.e., hematophagy). This feeding behavior presents a great physiological challenge to insects, especially in Hemipteran species with a digestion ...
Bianca S. Henriques, Bruno Gomes, Samara G. da Costa, Caroline da Silva Moraes, Rafael D. Mesquita, Rafael D. Mesquita, Viv M. Dillon, Eloi de Souza Garcia, Eloi de Souza Garcia, Patricia Azambuja, Patricia Azambuja, Roderick J. Dillon, Fernando A. Genta, Fernando A. Genta   +13 more
doaj   +1 more source

The SINA1‐BSD1 Module Regulates Vegetative Growth Involving Gibberellin Biosynthesis in Tomato

Advanced Science, Volume 11, Issue 40, October 28, 2024.
This study reveals how plant growth is controlled by a protein regulatory module SINA1‐BSD1. SINA1 is an enzyme that regulates the growth activator BSD1 through protein degradation. This regulation ultimately affects the production of gibberellin, a crucial plant growth hormone.
Yulin Yuan, Youhong Fan, Li Huang, Han Lu, Bowen Tan, Chloe Ramirez, Chao Xia, Xiangli Niu, Sixue Chen, Mingjun Gao, Cankui Zhang, Yongsheng Liu, Fangming Xiao   +12 more
wiley   +1 more source

Functional profiles of coronal and dentin caries in children

Journal of Oral Microbiology, 2018
Background: Dental caries results from a dysbiosis of tooth-associated biofilms and frequently extends through enamel into dentin which has a different structure and composition.
Christine A Kressirer, Tsute Chen, Kristie Lake Harriman, Jorge Frias-Lopez, Floyd E Dewhirst, Mary A Tavares, Anne CR Tanner   +6 more
doaj   +1 more source

Snapshots of Pseudomonas aeruginosa SOS response activation complex reveal structural prerequisites for LexA engagement and cleavage

bioRxiv
Antimicrobial resistance represents a major threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency.
Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, M. Chinellato, A. Grinzato, Francesco Filippini, L. Maso, A. Jakobi, L. Cendron   +10 more
semanticscholar   +1 more source

MCRS2 represses the transactivation activities of Nrf1

BMC Cell Biology, 2009
Background Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNC-bZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with distinct partners, such as Maf, FosB, c-Jun,
Wu Shan-Fu, Lin Yu-Jen, Yang Chi-Chiang, Lin Young-Sun, Wu Jia-Long, Lin Ying-Ting, Huang Chien-Fu   +6 more
doaj   +1 more source

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors [PDF]

, 2013
Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its ...
Aerbajinai, Albers, Aslam, Avram, Avram, Baker, Benoit, Berry, Chun Ming Chan, Cismasiu, Cismasiu, Collins, Coulthard, Cristina Montiel-Duarte, David M. Heery, Escher, Filipe, Frances R. Wadelin, Gui, Gurnell, Hall, Heery, Heery, Hilary M. Collins, Hu, Huang, Huggins, Joel Fulton, Kalkhoven, Kiefer, Kobayashi, Kobayashi, Kruse, Kuo, le Maire, Leid, Lettre, Liberati, Lim, Lin, Lin, Liu, Marban, Menzel, Monaghan, Nagy, Nakamura, Neetu Bharti, Nigel P. Mongan, Paula M. Moran, Peng, Perissi, Rohr, Rouleau, Sankaran, Sankaran, Sankaran, Satterwhite, Senawong, Sheppard, Song, Takezawa, Topark-Ngarm, Torchia, Tsai, Uda, Wang, Watson, Xie, Xie, Xu, Xu, Xu, Yu, Zhang, Zhu   +75 more
core   +2 more sources

Using Drosophila amyloid toxicity models to study Alzheimer's disease

Annals of Human Genetics, Volume 88, Issue 5, Page 349-363, September 2024.
Abstract Alzheimer's disease (AD) is the most prevalent form of dementia and is characterised by a progressive loss of neurons, which manifests as gradual memory decline, followed by cognitive loss. Despite the significant progress in identifying novel biomarkers and understanding the prodromal pathology and symptomatology, AD remains a significant ...
Elli Tsintzas, Teresa Niccoli
wiley   +1 more source

Interconversion between bound and free conformations of LexA orchestrates the bacterial SOS response [PDF]

, 2011
The bacterial SOS response is essential for the maintenance of genomes, and also modulates antibiotic resistance and controls multidrug tolerance in subpopulations of cells known as persisters.
Ana Rems, Blainey, Butala, Butala, Cascales, Cirz, Cohen, Courcelle, Daniel Klose, Darja Žgur-Bertok, Dorr, Dorr, Fernandez De Henestrosa, Galkin, Giese, Gowers, Gregor Anderluh, Heinz-Jürgen Steinhoff, Humphrey, Jeschke, Jiang, Johann P. Klare, Keseler, Klare, Kohanski, Kristan, Kristan, Lewis, Little, Little, Lu, Luo, Mackerell, Martin, Matej Butala, Miller, Mohana-Borges, Mrak, Mustard, Napolitano, Neher, Oertel-Buchheit, Pannier, Pawlowski, Polyhach, Pruteanu, Rich, Sassanfar, Steinhoff, Stephen J. W. Busby, Vesna Hodnik, Wade, Zdravko Podlesek, Zhang   +53 more
core   +2 more sources