Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 342, Issue 3, Page 212-240, May 2024.Branchio‐oto‐renal syndrome (BOR), which results in hearing loss and craniofacial defects, is caused by mutations in either SIX1, SIX5, or EYA1. However, the underlying genetic cause is unknown in about 50% of patients. We used transcriptomics, proteomics, and yeast 2‐hybrid approaches in Xenopus embryos to identify new putative candidate genes of BOR.
Scott J. Neal +7 more
wiley +1 more source
Aging Cell, Volume 23, Issue 5, May 2024.α‐Synuclein (α‐syn) is a hallmark protein of Parkinson's disease. It affects multiple protein stabilities disturbing cellular proteostasis. α‐Synuclein interacts in yeast with the proteasomal chaperone Rpn14, which corresponds to mammalian PAAF1. Activities of the 26S proteasome are inhibited by α‐syn through Rpn14/PAAF1.
Dajana Galka +10 more
wiley +1 more source
The Role of the Exo-Xis Region in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages [PDF]
, 2015 Previous studies indicated that these genetic elements could be involved in the regulation of lysogenization and prophage induction processes. The effects were dramatic in Shiga toxin-converting phage Φ24B after treatment with oxidative stress-inducing ...
Bloch, Sylwia +6 more
core +4 more sources
Borrelia burgdorferi PlzA is a cyclic‐di‐GMP dependent DNA and RNA binding protein
Molecular Microbiology, Volume 121, Issue 5, Page 1039-1062, May 2024.PlzA is the only universally encoded cyclic‐di‐GMP binding protein in Lyme disease spirochetes. The mechanism by which PlzA exerts effector functions was previously unknown. We report that PlzA is a c‐di‐GMP dependent DNA and RNA binding protein. Our model proposes that cellular levels of c‐di‐GMP modulate the binding affinity and/or specificity of ...
Nerina Jusufovic +8 more
wiley +1 more source
The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time [PDF]
, 2006 Peer ...
Andrulis ED +51 more
core +2 more sources
Reconstitution of an SOS Response Pathway Derepression of Transcription in Response to DNA Breaks [PDF]
E. coli responds to DNA damage by derepressing the transcription of about 20 genes that make up the SOS pathway. Genetic analyses have shown that SOS induction in response to double-stranded DNA (dsDNA) breaks requires LexA repressor, and the RecA and ...
Anderson, Daniel G +1 more
core +1 more source
Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development [PDF]
, 2006 The post-transcriptional control of gene expression is becoming increasingly important in the understanding of regulated events in eukaryotic cells. The parasitic kinetoplastids have a unique reliance on such processes, because their genome is organized ...
Athina Paterou +48 more
core +1 more source
Genetic Analysis of the Bovine Papillomavirus E2 Transcriptional Activation Domain [PDF]
, 1996 The bovine papillomavirus type 1 E2 transactivator has a large amino-terminal 215-residue transcriptional activation domain (TAD) that is active inSaccharomyces cerevisiaeand higher eukaryotic cells.
Androphy, Elliot J. +2 more
core +1 more source
Modulació de la inducció del sistema de reparació d'emergència (SOS) a Escherichia coli per la regió amino-terminal de la proteïna RecA [PDF]
, 1989 The amino-terminal fragment of the RecA protein was cloned in pUA27 plasmid and introduced in different repair mutants of F.scherichia coli. The UV-mediated induction of several SOS functions was then studied. Results show that the truncated RecA protein
Barbé Garcia, Jordi +3 more
core +1 more source
Complete Assembly of the Genome of an Acidovorax citrulli Strain Reveals a Naturally Occurring Plasmid in This Species [PDF]
, 2019 Acidovorax citrulli is the causal agent of bacterial fruit blotch (BFB), a serious threat to cucurbit crop production worldwide. Based on genetic and phenotypic properties, A.
Chen, Gong +6 more
core +1 more source