Results 11 to 20 of about 9,038 (230)
Interaction of Escherichia coli RecA Protein with LexA Repressor [PDF]
Journal of Biological Chemistry, 1996 The Escherichia coli RecA protein is involved in SOS induction, DNA repair, and homologous recombination. In vitro, RecA protein serves as a co-protease to cleave LexA repressor, the repressor of the SOS regulon; in addition, RecA protein promotes homologous pairing and DNA strand exchange, steps important to homologous recombination and DNA repair. To
Frank G. Harmon +2 more
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Global analysis of the regulon of the transcriptional repressor LexA, a key component of SOS response in Mycobacterium tuberculosis. [PDF]
J Biol Chem, 2012 Smollett KL +5 more
europepmc +3 more sources
Interaction of the LexA repressor and the uvrC regulatory region [PDF]
FEBS Letters, 1989 We have studied the in vitro interaction of the LexA repressor protein and the uvrC regulatory region. We find that there is specific binding to two regions, the region we have defined as lexA1 and the lexA2‐lexA3 region. Our findings support the possibility of an inducible regulation for this complex operon.
Thomas F. Stark, R E Moses
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A LexA mutant repressor with a relaxed inter‐domain linker [PDF]
Protein Science, 1998 AbstractThe LexA protein is part of a large family of prokaryotic transcriptional repressors that contain an amino‐terminal DNA binding domain and a carboxy‐terminal dimerization domain. These domains are separated by a linker or hinge region, which is generally considered to be rather flexible and unconstrained. So far, no structure of any of the full‐
Pascale Oertel‐Buchheit +4 more
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Autodigestion of lexA and phage lambda repressors. [PDF]
Proceedings of the National Academy of Sciences, 1984 Proteolytic cleavage of lexA repressor is an early step in derepression of the SOS regulatory system of Escherichia coli. In vivo and in vitro data have indicated a role for recA protein in this specific proteolytic reaction. I show here that, under certain conditions, specific in vitro cleavage of highly-purified lexA protein can take place in the ...
John W. Little
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Roles of Alp and Prt Regulons in the Response of Pseudomonas aeruginosa to UV-C Light. [PDF]
Environ Microbiol RepOur results show that LexA‐regulated genes are the first to be induced after DNA damage, while autolysis functions controlled by the Alp system are the last. Death by UV is mediated primarily by Alp or Prt systems, depending on the Pseudomonas aeruginosa subline. ABSTRACT UV light is a well‐studied environmental DNA damaging agent.
Fonseca MRB +6 more
europepmc +2 more sources
A mutant LexA repressor harboring a cleavage motif cysteine‐glycine remains inducible [PDF]
FEBS Letters, 1988 Using site‐directed mutagenesis of the lexA gene we have changed the amino acid Ala‐84 of the LexA repressor for a cysteine. The reason for this change was the striking homology between LexA and UmuD and the comparable size of the two amino acid side chains.
Michèle Granger‐Schnarr +2 more
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Exploration of inhibitors of the bacterial LexA repressor-protease
Bioorganic & Medicinal Chemistry Letters, 2022 Resistant and tolerant bacterial infections lead to billions in healthcare costs and cause hundreds of thousands of deaths each year. The bulk of current antibiotic research efforts focus on molecules which, although novel, are not immune from acquired resistance and seldomly affect tolerant populations.
Ana Victoria Cheng Jaramillo +4 more
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cI and lexA repressors consist of three cro‐like domains [PDF]
FEBS Letters, 1982 Oleg B. Ptitsyn +3 more
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The bacterial LexA transcriptional repressor
Cellular and Molecular Life Sciences, 2008 Bacteria respond to DNA damage by mounting a coordinated cellular response, governed by the RecA and LexA proteins. In Escherichia coli, RecA stimulates cleavage of the LexA repressor, inducing more than 40 genes that comprise the SOS global regulatory network.
Matej Butala +2 more
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