Results 11 to 20 of about 115,119 (230)
Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor [PDF]
Structure, 2019 Bacteria identify and respond to DNA damage using the SOS response. LexA, a central repressor in the response, has been implicated in the regulation of lysogeny in various temperate bacteriophages. During infection of Bacillus thuringiensis with GIL01 bacteriophage, LexA represses the SOS response and the phage lytic cycle by binding DNA, an ...
Nathanael A. Caveney +8 more
semanticscholar +6 more sources
Interaction of Escherichia coli RecA Protein with LexA Repressor [PDF]
Journal of Biological Chemistry, 1996 Essential to the two distinct cellular events of genetic recombination and SOS induction in Escherichia coli, RecA protein promotes the homologous pairing and exchange of DNA strands and the proteolytic cleavage of the LexA repressor, respectively.
William M. Rehrauer +4 more
semanticscholar +12 more sources
Elucidating the Substrate Preference of the Bi-Functional Repressor-Protease LexA [PDF]
Biophysical Journal, 2013 The rise of drug resistance in bacteria is a growing problem, and poses a formidable medical and scientific challenge. Mutations - the driving force behind evolution and drug-resistance - have long been thought to arise spontaneously in bacteria, leading to the pessimistic view that the rise of drug resistance is inevitable. However, the acquisition of
Charlie Y. Mo
semanticscholar +4 more sources
Exploration of inhibitors of the bacterial LexA repressor-protease
Bioorganic & Medicinal Chemistry Letters, 2022 Resistant and tolerant bacterial infections lead to billions in healthcare costs and cause hundreds of thousands of deaths each year. The bulk of current antibiotic research efforts focus on molecules which, although novel, are not immune from acquired resistance and seldomly affect tolerant populations.
Ana Victoria Cheng Jaramillo +4 more
semanticscholar +5 more sources
Purified lexA protein is a repressor of the recA and lexA genes. [PDF]
Proceedings of the National Academy of Sciences, 1981 Escherichia coli shows a pleiotropic response (the SOS response) to treatments that damage DNA or inhibit DNA replication. Previous evidence has suggested that the product of the lexA gene is involved in regulating the SOS response, perhaps as a ...
John W. Little +2 more
semanticscholar +5 more sources
In Situ Single-Molecule Dynamics of the SOS-Repressor Lexa during Antibiotic Stress [PDF]
Biophysical Journal, 2020 Leonard Schärfen +3 more
semanticscholar +4 more sources
Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionAs antibiotic resistance has become more prevalent, the social and economic impacts are increasingly pressing. Indeed, bacteria have developed the SOS response which facilitates the evolution of resistance under genotoxic stress.
Zachariah P. Schuurs +7 more
doaj +2 more sources
Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12 [PDF]
Journal of Bacteriology, 1988 The LexA repressor of Escherichia coli represses a set of genes that are expressed in the response to DNA damage. After inducing treatments, the repressor is inactivated in vivo by a specific cleavage reaction which requires an activated form of RecA protein.
Lih-Ling Lin, John W. Little
semanticscholar +5 more sources
Nucleotide sequence binding specificity of the LexA repressor of Escherichia coli K-12 [PDF]
Journal of Bacteriology, 1985 The specificity of LexA protein binding was investigated by quantifying the repressibility of several mutant recA and lexA operator-promoter regions fused to the Escherichia coli galactokinase (galK) gene. The results of this analysis indicate that two sets of four nucleotides, one set at each end of the operator (terminal-nucleotide contacts), are ...
Kenneth F. Wertman, David W. Mount
semanticscholar +5 more sources
The bacterial LexA transcriptional repressor
Cellular and Molecular Life Sciences, 2008 Bacteria respond to DNA damage by mounting a coordinated cellular response, governed by the RecA and LexA proteins. In Escherichia coli, RecA stimulates cleavage of the LexA repressor, inducing more than 40 genes that comprise the SOS global regulatory network.
Matej Butala +2 more
semanticscholar +6 more sources