Bacteriophage crosstalk: coordination of prophage induction by trans-acting antirepressors. [PDF]
PLoS Genetics, 2011 Many species of bacteria harbor multiple prophages in their genomes. Prophages often carry genes that confer a selective advantage to the bacterium, typically during host colonization.
Sébastien Lemire +2 more
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Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12 [PDF]
Journal of Bacteriology, 1988 The LexA repressor of Escherichia coli represses a set of genes that are expressed in the response to DNA damage. After inducing treatments, the repressor is inactivated in vivo by a specific cleavage reaction which requires an activated form of RecA protein.
Lih-Ling Lin, John W. Little
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Amino acid diversity in LexA repressor sequence among ESKAPE pathogens
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 Rio Risandiansyah
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Cells, 2021 Deinococcus bacteria are extremely resistant to radiation and able to repair a shattered genome in an essentially error-free manner after exposure to high doses of radiation or prolonged desiccation.
Laurence Blanchard, Arjan de Groot
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Identification of EppR, a Second Repressor of Error-Prone DNA Polymerase Genes in Acinetobacter baumannii. [PDF]
Mol MicrobiolA novel TetR‐like regulator (EppR) has been identified to repress genes encoding DNA polymerase V in Acinetobacter baumannii through the direct binding of a conserved EppR motif in their promoters. EppR works with previously identified regulator UmuDAb to serve as co‐regulators of these genes. In response to DNA damage and/or environmental stress, both
Nguyen B +6 more
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DNA Sampling: a method for probing protein binding at specific loci on bacterial chromosomes [PDF]
, 2009 We describe a protocol, DNA sampling, for the rapid isolation of specific segments of DNA, together with bound proteins, from Escherichia coli K-12. The DNA to be sampled is generated as a discrete fragment within cells by the yeast I-SceI meganuclease ...
Blattner +29 more
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Solution structure of the LexA repressor DNA binding domain determined by 1H NMR spectroscopy. [PDF]
The EMBO Journal, 1994 The structure of the 84 residue DNA binding domain of the Escherichia coli LexA repressor has been determined from NMR data using distance geometry and restrained molecular dynamics. The assignment of the 1H NMR spectrum of the molecule, derived from 2- and 3-D homonuclear experiments, is also reported.
Rasmus H. Fogh +5 more
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Frontiers in Microbiology, 2016 LexA is a well-established transcriptional repressor of SOS genes induced by DNA damage in E. coli and other bacterial species. However, LexA in the cyanobacterium Synechocystis sp. PCC 6803 has been suggested not to be involved in SOS response.
Ayumi eKizawa +5 more
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Binding of the Bacillus subtilis LexA protein to the SOS operator [PDF]
, 2005 The Bacillus subtilis LexA protein represses the SOS response to DNA damage by binding as a dimer to the consensus operator sequence 5′-CGAACN(4)GTTCG-3′.
Banky, Poopak +12 more
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Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response. [PDF]
PLoS ONE, 2013 Bacteria activate a regulatory network in response to the challenges imposed by DNA damage to genetic material, known as the SOS response. This system is regulated by the RecA recombinase and by the transcriptional repressor lexA.
Luciane S Fonseca +9 more
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