Results 41 to 50 of about 115,119 (230)

Genome-Wide Identification of the LexA-Mediated DNA Damage Response in Streptomyces venezuelae

bioRxiv, 2022
The transcriptional regulator LexA functions as a repressor of the bacterial SOS response, which is induced under DNA-damaging conditions. This results in the expression of genes important for survival and adaptation.
Kathryn J. Stratton, Matthew J. Bush, G. Chandra, C. Stevenson, K. Findlay, Susan Schlimpert   +5 more
semanticscholar   +1 more source

Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response. [PDF]

PLoS ONE, 2013
Bacteria activate a regulatory network in response to the challenges imposed by DNA damage to genetic material, known as the SOS response. This system is regulated by the RecA recombinase and by the transcriptional repressor lexA.
Luciane S Fonseca, Josefa B da Silva, Juliana S Milanez, Claudia B Monteiro-Vitorello, Leonardo Momo, Zenaide M de Morais, Silvio A Vasconcellos, Marilis V Marques, Paulo L Ho, Renata M A da Costa   +9 more
doaj   +1 more source

Binding of the Bacillus subtilis LexA protein to the SOS operator [PDF]

, 2005
The Bacillus subtilis LexA protein represses the SOS response to DNA damage by binding as a dimer to the consensus operator sequence 5′-CGAACN(4)GTTCG-3′.
Banky, Poopak, Burnett, Peta-Gaye G., Calderon, Georgina L., Dwyer, Erica C., Fuller, Shakierah N., Gebre, Biniam, Groban, Eli S., Johnson, Martha B., King, Leah M., Lovett, Charles M., O'Gara, Thomas M., Sheren, Ila N., Von Mutius, Lindi D.   +12 more
core   +3 more sources

Single-molecule imaging of LexA degradation in Escherichia coli elucidates regulatory mechanisms and heterogeneity of the SOS response

Nature Microbiology, 2021
The bacterial SOS response represents a paradigm of gene networks controlled by a master transcriptional regulator. Self-cleavage of the SOS repressor LexA induces a wide range of cell functions that are critical for survival and adaptation when bacteria
E. Jones, Stephan Uphoff
semanticscholar   +1 more source

RNA-seq profiling reveals novel target genes of LexA in the cyanobacterium Synechocystis sp. PCC 6803

Frontiers in Microbiology, 2016
LexA is a well-established transcriptional repressor of SOS genes induced by DNA damage in E. coli and other bacterial species. However, LexA in the cyanobacterium Synechocystis sp. PCC 6803 has been suggested not to be involved in SOS response.
Ayumi eKizawa, Akihito eKawahara, Yasushi eTakimura, Yoshitaka eNishiyama, Yukako eHihara, Yukako eHihara   +5 more
doaj   +1 more source

Stochastic analysis of the SOS response in Escherichia coli. [PDF]

PLoS ONE, 2009
BACKGROUND: DNA damage in Escherichia coli evokes a response mechanism called the SOS response. The genetic circuit of this mechanism includes the genes recA and lexA, which regulate each other via a mixed feedback loop involving transcriptional ...
Yishai Shimoni, Shoshy Altuvia, Hanah Margalit, Ofer Biham   +3 more
doaj   +1 more source

cI and lexA repressors consist of three cro‐like domains [PDF]

FEBS Letters, 1982
Oleg B. Ptitsyn, Alexei V. Finkelstein, М. П. Кирпичников, K. G. Skryabin   +3 more
openalex   +4 more sources

DNA Sampling: a method for probing protein binding at specific loci on bacterial chromosomes [PDF]

, 2009
We describe a protocol, DNA sampling, for the rapid isolation of specific segments of DNA, together with bound proteins, from Escherichia coli K-12. The DNA to be sampled is generated as a discrete fragment within cells by the yeast I-SceI meganuclease ...
Blattner, Busby, Butala, Butala, Dame, David J. Lee, Dejardin, Gadgil, Grainger, Grainger, Griffin, Herring, Karp, Kuhar, Lee, Lodge, Matej Butala, Miller, Minchin, Mulec, Murphy, Nordhoff, Pope, Salgado, Spott, Stead, Stephen J. W. Busby, Wang, Westblade, Woo   +29 more
core   +5 more sources

Cd-induced cytosolic proteome changes in the cyanobacterium Anabaena sp. PCC7120 are mediated by LexA as one of the regulatory proteins

bioRxiv, 2022
LexA, a well-characterized transcriptional repressor of the SOS genes in heterotrophic bacteria, has been shown to regulate diverse genes in cyanobacteria. An earlier study showed that LexA overexpression in a cyanobacterium, Anabaena sp. PCC7120 reduces
A. Srivastava, Arvind Kumar, S. Biswas, V. Srivastava, H. Rajaram, Y. Mishra   +5 more
semanticscholar   +1 more source

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]

PLoS ONE, 2008
Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long, Nicholas Renzette, Richard C Centore, Steven J Sandler   +3 more
doaj   +1 more source