Results 151 to 160 of about 264,833 (258)

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

Derivatization of pBACpAK entrapment vectors for enhanced mobile genetic element transposition detection in multidrug-resistant Escherichia coli. [PDF]

Access Microbiol
Tansirichaiya S, Leartsiwawinyu W, Thanawan N, Goodman RN, Tribuddharat C, Roberts AP.   +5 more
europepmc   +1 more source

Fn14 Controls the SIRT2‐Mediated Deacetylation of Slug to Inhibit the Metastasis of Epithelial Ovarian Cancer

Advanced Science, EarlyView.
It is reported that Fn14 inhibited EOC metastasis by regulating Slug‐mediated EMT. Furthermore, Fn14 altered the subcellular localization of SIRT2 by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug.
Anyue Wu, Shengze Li, Chunyang Feng, Ruiju He, Ruolan Wu, Zhijun Hu, Jinhua Huang, Wenjing Wang, Lei Huang, Lihua Qiu   +9 more
wiley   +1 more source

Novel mutations in the <i>marR</i> gene (<i>MAB_2648c</i>) modify nitroxoline activity in <i>Mycobacterium abscessus</i>. [PDF]

Antimicrob Agents Chemother
Xu P, Li Y, Xu B, Cao D, Dong X, Xiang Y, Jiang X, Yuan X, Qiu Y, Zhang Y.   +9 more
europepmc   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Structural Characterisation of TetR/AcrR Regulators in <i>Streptomyces fildesensis</i> So13.3: An In Silico CRISPR-Based Strategy to Influence the Suppression of Actinomycin D Production. [PDF]

Int J Mol Sci
Leal K, Machuca J, Gajardo H, Palma M, Contreras MJ, Nuñez-Montero K, Gutiérrez Á, Barrientos L.   +7 more
europepmc   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source

Control of Snail1 protein stability by post-translational modifications: the basis for a complex regulation of Snail1 function. [PDF]

Int J Biol Sci
García de Herreros A.
europepmc   +1 more source

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

Different mutations in TBL1XR1 lead to diverse phenotypes of neurodevelopmental disorder: two case reports. [PDF]

BMC Med Genomics
Wei L, Yang Y, Jiang T, Zhang C, Chen C, Huang M, Li N, Xiong H, Gao F.   +8 more
europepmc   +1 more source