Results 121 to 130 of about 1,188,104 (349)

Reproducibility Performance Test of Multi Metal Oxide Catalyst in Selective Oxidation of Propane using Combinatorial Technology [PDF]

, 2014
The concept of rapid catalyst screening using combinatorial technology was applied in the development of selective oxidation catalyst. In this paper, the design, Design of Experiment (DOE) and catalytic results are discussed to demonstrate the ...
Abd Hamid, Sharifah Bee, Widi, Restu Kartiko   +1 more
core  

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Progress on reproducibility [PDF]

Science, 2018
Ideas supported by well-defined and clearly described methods and evidence are one of the cornerstones of science. After several publications indicated that a substantial number of scientific reports may not be readily reproducible, the scientific community and public began engaging in discussions about mechanisms to measure and enhance the ...
openaire   +3 more sources

Acute post-exercise cardiovascular responses in healthy participants [PDF]

The overall aim of this project was to investigate the acute cardiovascular post-exercise response in healthy individuals. The aim of the first study was to establish the within day and between day reproducibility of supine and tilt baroreflex ...
Reynolds, Linda J
core  

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Reproducibility Report for "Learning To Count Objects In Natural Images For Visual Question Answering" [PDF]

arXiv, 2018
This is the reproducibility report for the paper "Learning To Count Objects In Natural Images For Visual QuestionAnswering"
arxiv  

Interactive Tools for Reproducible Science -- Understanding, Supporting, and Motivating Reproducible Science Practices [PDF]

arXiv, 2020
Reproducibility should be a cornerstone of science as it enables validation and reuse. In recent years, the scientific community and the general public became increasingly aware of the reproducibility crisis, i.e. the wide-spread inability of researchers to reproduce published work, including their own.
arxiv  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Integration of “omics” Data and Phenotypic Data Within a Unified Extensible Multimodal Framework

Frontiers in Neuroinformatics, 2018
Analysis of “omics” data is often a long and segmented process, encompassing multiple stages from initial data collection to processing, quality control and visualization. The cross-modal nature of recent genomic analyses renders this process challenging
Samir Das, Samir Das, Xavier Lecours Boucher, Xavier Lecours Boucher, Christine Rogers, Christine Rogers, Carolina Makowski, Carolina Makowski, Carolina Makowski, François Chouinard-Decorte, François Chouinard-Decorte, Kathleen Oros Klein, Kathleen Oros Klein, Natacha Beck, Natacha Beck, Pierre Rioux, Pierre Rioux, Shawn T. Brown, Shawn T. Brown, Zia Mohaddes, Zia Mohaddes, Cole Zweber, Cole Zweber, Victoria Foing, Victoria Foing, Marie Forest, Marie Forest, Kieran J. O’Donnell, Kieran J. O’Donnell, Joanne Clark, Michael J. Meaney, Michael J. Meaney, Celia M. T. Greenwood, Celia M. T. Greenwood, Alan C. Evans, Alan C. Evans   +35 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source