Results 121 to 130 of about 2,089,944 (391)

A manifesto for reproducible science. [PDF]

Nature Human Behaviour, 2017
AbstractImproving the reliability and efficiency of scientific research will increase the credibility of the published scientific literature and accelerate discovery. Here we argue for the adoption of measures to optimize key elements of the scientific process: methods, reporting and dissemination, reproducibility, evaluation and incentives.
Christopher D. Chambers, Uri Simonsohn, Jennifer J. Ware, Nathalie Percie du Sert, Brian A. Nosek, Brian A. Nosek, John P. A. Ioannidis, Katherine S. Button, Eric-Jan Wagenmakers, Dorothy V. M. Bishop, Marcus R. Munafò   +10 more
openaire   +8 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Progress Update and Challenges on V.O2max Testing and Interpretation

Frontiers in Physiology, 2020
The maximal oxygen uptake (V.O2max) is the primary determinant of endurance performance in heterogeneous populations and has predictive value for clinical outcomes and all-cause mortality.
Marcos Martin-Rincon, Marcos Martin-Rincon, Jose A. L. Calbet, Jose A. L. Calbet, Jose A. L. Calbet   +4 more
doaj   +1 more source

Use of Microtome Sections to Determine the Effect of Retention Aid on Filler Distribution [PDF]

, 1964
Two-sidedness of paper is an all too common problem in the paper industry. Most of the undesirable results are due to the uneven distribution of filler in the sheet.
Farrand, James
core   +1 more source

Entangled states that cannot reproduce original classical games in their quantum version

, 2004
A model of a quantum version of classical games should reproduce the original classical games in order to be able to make a comparative analysis of quantum and classical effects.
Benjamin, Du, Dür, Eisert, Fumiaki Morikoshi, Han, Iqbal, Johnson, Junichi Shimamura, Koashi, Lee, Mandel, Meyer, Nobuyuki Imoto, Shimamura, van Enk, Özdemir, Şahin Kaya Özdemir   +17 more
core   +1 more source

Reproducibility blues [PDF]

The EMBO Journal, 2015
Research findings advance science only if they are significant, reliable and reproducible. Scientists and journals must publish robust data in a way that renders it optimally reproducible. Reproducibility has to be incentivized and supported by the research infrastructure but without dampening innovation.
openaire   +3 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Reproducibility for Everyone - Introduction to Reproducibility

, 2019
This presentation forms part of a eight-series presentation set covering various aspects of reproducibility. The presentation was developed by Reproducibility for Everyone. For more information visit their website - http://www.repro4everyone.org.The Introduction to Reproducibility provide context and motivation for caring about reproducibility in ...
Abitua, Angela, Clyburne-Sherin, April, Schwessinger, Benjamin, Alicea, Bradly, Ganguly, Diep, Kamens, Joanne, Teytelman, Lenny, Schmelling, Nicolas, Roy, Sonali, Weissgerber, Tracey L.   +9 more
openaire   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source