Results 71 to 80 of about 690,617 (311)

High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method

Biomedicines
The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency.
Nicolas Dufour, Raphaëlle Delattre, Laurent Debarbieux   +2 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Reproducibility of neuroimaging analyses across operating systems

Frontiers in Neuroinformatics, 2015
Neuroimaging pipelines are known to generate different results depending on the computing platform where they are compiled and executed. We quantify these differences for brain tissue classification, fMRI analysis, and cortical thickness (CT) extraction,
Tristan eGlatard, Tristan eGlatard, Lindsay Burke Lewis, Rafael Ferreira da Silva, Reza eAdalat, Natacha eBeck, Claude eLepage, Pierre eRioux, Marc-Etienne eRousseau, Tarek eSherif, Ewa eDeelman, Najmeh eKhalili-Mahani, Alan Charles Evans   +12 more
doaj   +1 more source

“statcheck”: Automatically detect statistical reporting inconsistencies to increase reproducibility ofmeta‐analyses [PDF]

, 2020
Michèle B. Nuijten, Joshua R. Polanin
openalex   +1 more source

Tissue Barrier-on-Chip: A Technology for Reproducible Practice in Drug Testing [PDF]

, 2022
Eugen Koch, Verena Ledwig, Sebastian Bendas, Stephan Reichl, Andreas Dietzel   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Interacting with Annotated and Synchronized Music Corpora on the Dezrann Web Platform

Transactions of the International Society for Music Information Retrieval
Open datasets with annotated corpora are crucial to foster research in music information retrieval (MIR) studies and to disseminate knowledge towards musicians and the general public.
Charles Ballester, Baptiste Bacot, Louis Bigo, Vanessa Nina Borsan, Louis Couturier, Ken Déguernel, Quentin Dinel, Laurent Feisthauer, Klaus Frieler, Mark Gotham, Richard Groult, Johannes Hentschel, Alexandre d'Hooge, Dinh-Viet-Toan Le, Florence Levé, Francesco Maccarini, Ivana Maričić, Gianluca Micchi, Meinard Müller, Alexandros Stamatiadis, Tom Taffin, Patrice Thibaud, Christof Weiß, Rui Yang, Emmanuel Leguy, Mathieu Giraud   +25 more
doaj   +1 more source

Psychophysiological Interactions in a Visual Checkerboard Task: Reproducibility, Reliability, and the Effects of Deconvolution

Frontiers in Neuroscience, 2017
Psychophysiological interaction (PPI) is a regression based method to study task modulated brain connectivity. Despite its popularity in functional MRI (fMRI) studies, its reliability and reproducibility have not been evaluated.
Xin Di, Bharat B. Biswal
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Reliability of 2D motion analysis software for evaluation of dynamic smile asymmetry using smartphone technology

Clinical and Investigative Orthodontics
Aim To evaluate the reliability of a free motion analysis method in the evaluation of the 2D dynamic asymmetry of smiles using smartphone technology.Materials and methods Twenty-six healthy adult females were included in this study. Four facial bilateral
Dhelal Al-Rudainy, Hadeel Adel Al-Lami, Talib Al-Ameri, Liu Yang   +3 more
doaj   +1 more source