Genetic determination of reproduction rate traits in dairy cattle breeding
, 2021 S. Ruban, Мykhailo Matvieiev
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Thick-billed Longspur ( Rhynchophanes mccownii ) reproduction shows minimal short-term response to conservation-based program [PDF]
, 2022 Kaitlyn M. Reintsma +3 more
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HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
The role of bioelements ‒ components of free radical oxidation ‒ in the genesis of childhood obesity
Сибирский научный медицинский журналCurrently, there is no common understanding of the bioelement status of obese children and adolescents. In this regard, we have summarized the available data on open access and presented information on the role and content of bioelements involved in the ...
A. S. Lesnaya +6 more
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
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NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Response to comment on: Gleicher N et al., 2016. Reprod biol endocrinol Sep 5;14(1):54
Reproductive Biology and Endocrinology, 2017 Norbert Gleicher +8 more
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Jacques DUFRESNE, la Reproduction humaine industrialisée , Diagnostic 2, Institut québécois de recherche sur la culture, 1986, 125 p. [PDF]
, 1987 Jacques Dufresne
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