Results 111 to 120 of about 870,336 (295)

The multiple actions of grape and its polyphenols on female reproductive processes with an emphasis on cell signalling

Frontiers in Endocrinology
Grapes are an economically important fruit crop, and their polyphenols (mainly phenolic acids, flavanols, flavonols, anthocyanins, proanthocyanidins, and stilbenes) can exert a wide range of health benefits as an interesting and valuable dietary ...
Ladislav Kohut, Simona Baldovska, Michal Mihal, Lubomir Belej, Alexander V. Sirotkin, Shubhadeep Roychoudhury, Adriana Kolesarova, Adriana Kolesarova   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens.

, 1988
Plants have physical and chemical mechanisms for defense from attack by animals. Phytochemical defenses that protect plants from attack by insects include antifeedants, insecticides, and insect growth regulators.
Hughes, CL, C L Hughes
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

, 2006
Phthalates adversely affect the male reproductive system in animals. We investigated whether phthalate monoester contamination of human breast milk had any influence on the postnatal surge of reproductive hormones in newborn boys as a sign of testicular ...
Boisen, Kirsten A, Ida M. Schmidt, Skakkebaek, Niels E, Marla Chellakooty, Marko M. Kaleva, Ida N. Damgaard, Suomi, Anne-Maarit, Gerda K. Mortensen, Main, Katharina M, Kaleva, Marko M, Helena E. Virtanen, Jorma Toppari, Chellakooty, Marla, Jørgen H. Petersen, Mortensen, Gerda Krog, Virtanen, Helena E, Toppari, Jorma, Andersson, Anna-Maria, Kirsten A. Boisen, Anna-Maria Andersson, Anne-Maarit Suomi, Damgaard, Ida N, Petersen, Jørgen Holm, Schmidt, Ida M, Niels E. Skakkebæk, Katharina M. Main   +25 more
core   +2 more sources

Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health

Medical Review
This review thoroughly explores the multifaceted roles of sexual hormones, emphasizing their impact beyond reproductive functions and underscoring their significant influence on cardiometabolic regulation.
Xega Viktoria, Liu Jun-Li
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Medications and Hormones for Reproductive Problems

, 1972
The following comments are on reproductive therapy used by five herd health oriented practices in Northeastern Wisconsin (1). New developments such as Prostaglandin and Gonadotrophic hormone releasing factors may be interesting products for the near ...
Koritansky, Richard C.
core  

The economic effect of cow-based reproductive management programs with a systematic use of reproductive hormones

Journal of Dairy Science
: Hormone-based reproductive management programs can be beneficial to improve dairy cow's reproductive performance. This study aimed to compare the economic impact of reproductive management programs using systematic hormonal treatments to individual ...
A. Wicaksono, F. Edwardes, W. Steeneveld, B.H.P. van den Borne, P. Pinho, F. Randi, H. Hogeveen   +6 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source