Results 81 to 90 of about 870,336 (295)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Realization of Bos taurus reproductive capacity by means of hormonal regulation (review)

Siberian Journal of Life Sciences and Agriculture
Background. Hormones are biologically active substances that interact with each other and regulate physiological and metabolic processes in the body of farm animals.
Alexey N. Frolov, Oleg A. Zavyalov, Timur B. Aldyarov, Erlan S. Medetov, Zulfiya A. Galieva   +4 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Evaluation of reproductive hormones and histological of ovary in female rats treatment with dexamethasone [PDF]

, 2019
The present study aimed to investigate the effect of dexamethasone Concentration on reproductive hormones and histochange of ovary in ...
Rana Talib Al-Muswie
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Brain-gonad axes harmonize male mating drive and reproductive strategy via steroid hormones

Nature Communications
The interplay between the nervous and reproductive systems, encapsulated by the brain-gonad axis, is pivotal for reproduction. However, it remains largely unclear how hormones released from reproductive system actively regulate male sexual behaviors and ...
Kexin Li, Yue Jin, Ting Liu, Hongkun Shan, Yi Lin, Wei Zhang   +5 more
doaj   +1 more source

Evaluation of Seminal Fluid Parameters, Reproductive Hormones and Testicular Biopsy for non-obstructive Azoospermic Patients with Sertoli cell only Syndrome

Sultan Qaboos University Journal for Science, 2006
The aims of this study were (i) to determine the seminal fluid parameters, levels of serum reproductive hormones, testicular size and diameter of seminiferous tubules depending on multiple testicular biopsies from non-obstructive azoospermic (NOA ...
Naso S. Qhraman, Muhammad-Baqir M-R. Fakhrildin, Dhaher H. Bra   +2 more
doaj   +1 more source

Leptin: a hormone of reproduction [PDF]

Human Reproduction, 1997
G S, Conway, H S, Jacobs
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source