Results 111 to 120 of about 223,319 (331)

Alachlor oxidation by the filamentous fungus Paecilomyces marquandii [PDF]

, 2013
Alachlor, a popular chloroacetanilide herbicide, can be a potential health risk factor. Soil microorganisms are primarily responsible for conversion and migration of alachlor in natural environment, but knowledge concerning alachlor biodegradation is not
Długoński, Jerzy, Piątek, Milena Adela, Szewczyk, Rafał, Słaba, Mirosława   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during the reproductive periods induces reproductive endocrine disorders in their offspring

Ecotoxicology and Environmental Safety
Microcystin-LR’s reproductive (reproductive and non-reproductive periods) and transgenerational toxicity in amphibians remains poorly understood. Adult Pelophylax nigromaculatus in reproductive and non-reproductive periods were exposed to MC-LR to ...
Huijuan Zhang, Yuefei Ruan, Zifang Ding, Zheng Li, Jun He, Jing Li, Pei Hong, Hailong Wu, Yilin Shu   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives

Ecotoxicology and Environmental Safety
A growing body of evidence exhibits the ubiquitous presence and accumulation of micro- and nanoplastics (MNPs) in the air, drinking water, food, and even inside the body, which has raised concerns about their potential impact on reproductive and ...
Zitong Zhang, Jiahua Meng, Jiaqi Tian, Ning Li, Zhen Chen, Xiang Yun, Dandan Song, Fei Li, Shuyin Duan, Lin Zhang   +9 more
doaj   +1 more source

Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats

, 2021
Duncan Turnbull, Maia M. Jack, Prägati Coder, Catherine A. Picut, Joseph V. Rodricks   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

QSAR Models for Reproductive Toxicity and Endocrine Disruption Activity

Molecules, 2010
Reproductive toxicity is an important regulatory endpoint, which is required in registration procedures of chemicals used for different purposes (for example pesticides).
Marjan Vračko, Marjana Novič
doaj   +1 more source

Emblica officinalis Garten fruits extract ameliorates reproductive injury and oxidative testicular toxicity induced by chlorpyrifos in male rats [PDF]

, 2013
Abir Lal Dutta, Chitta Ranjan Sahu
openalex   +1 more source

Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study [PDF]

, 2020
Guochao Ni, Xuhui Zhang, Seth Yaw Afedo, Rui Rong   +3 more
openalex   +1 more source