Results 121 to 130 of about 1,268,897 (251)
, 2017 Corpora lutea and implantation sites in numbers in reproductive/ developmental toxicity study in Wistar rats.
Naveed S (3812515) +4 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reproductive Toxicity of Quaternary Ammonium Compounds
As a proof of concept for a framework to integrate new approach methodologies into hazard identification and risk characterization, this systematic review will evaluate the reproductive toxicity of BACs and DDAC, two common quaternary ammonium ...
Tracey Woodruff +4 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
, 1996 Health and Safety Code 25249.5 et seq.) requires that the Governor cause to be published a list of those chemicals “known to the state ” to cause cancer or reproductive toxicity. The Act specifies that “a chemical is known to the state to cause cancer or
core
The long-term inhalation of free silica dust causes silicosis—a prevalent occupational hazard—yet its systemic effect on male reproductive toxicity remains underexplored.
Ling Zhang +21 more
core +1 more source
Reproductive toxicity of AgNPs in Drosophila melanogaster [PDF]
Els autors formen part del Grup de Mutagènes i Projecte Plasticheal. El pòster s'ha presentat a diverses jornades.Investigation about the internalization and reproductive toxicity of silver nanoparticles (AgNPs) in the fruit fly, Drosophila melanogaster.
Jornada de BioRecerca de la Facultat de Biociències de la Universitat Autònoma de Barcelona +5 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source