Results 121 to 130 of about 1,022,108 (300)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice

Male infertility, as a globally significant reproductive health issue, remains idiopathic in over 40% of cases. Reproductive disorders in males induced by environmental pollutants, such as di(2-ethylhexyl) phthalate (DEHP), have garnered considerable ...
Zhen Zhang, Liyang Ding, Bo Xu, Xufeng Fu, Yitong Shang, Yu Deng, Hong Yang   +6 more
core   +1 more source

Reproductive effects in male rats exposed to diuron

, 2015
Diuron is a ureic herbicide considered to have very low toxicity. The present study evaluated several aspects of reproductive toxicity of diuron in adult male rats. Diuron was diluted in corn oil and administered by oral gavage to groups of 18-20 rats at
Mercadante, A, Fernandes, GSA, Arena, AC, Fernandez, CDB, Fernandes, Glaura S A, Barbisan, Luís F, Kempinas, Wilma G, Arena, Arielle C, Kempinas, WG, Fernandez, Carla D B, Mercadante, Amauri, Barbisan, LF   +11 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Aryl Hydrocarbon Receptor Mediates the Neurodevelopmental Toxicity of Perfluorooctane Sulfonamide in Zebrafish Larvae

Perfluorooctane sulfonamide (PFOSA), the direct precursor to perfluorooctane sulfonate (PFOS), is widely present in the environment. Research has indicated that PFOSA is cardiotoxic and hepatotoxic, but its impact on neurodevelopment remains unclear.
Tao Chen, Yan Jiang, Jie Zhang, Pinyi Chen, Kang Wang   +4 more
core   +1 more source

Green and chemical synthesis of CuO nanoparticles: comparative reproductive toxicity evaluation at various phases and in offsprings

Materials Research Express
Metallic nanoparticles (NPs) are used in various biomedical applications due to their widespread utility. This study compares the reproductive toxicity of chemically synthesized CuO NPs (ChemSyn CuO NPs) and green synthesized CuO NPs (GrSyn CuO NPs) in ...
Sania Naz, Joham Sarfraz Ali, Muhammad Zia, Asif Mahmood, Waheed Al Masry, Haleema Masud, Muhammad Latif   +6 more
doaj   +1 more source

Advances in immunology of male reproductive toxicity induced by common environmental pollutants

Environment International
Humans are exposed to an ever-increasing number of environmental toxicants, some of which have gradually been identified as major risk factors for male reproductive health, even associated with male infertility.
Hao Li, Xin-Run Wang, Yi-Fan Hu, Yong-Wei Xiong, Hua-Long Zhu, Yi-Chao Huang, Hua Wang   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Fumonisin toxicity in ducks and turkeys [PDF]

, 2013
Les fumonisines (FBs) sont les principales mycotoxines produites par Fusarium verticillioides et Fusarium proliferatum, qui se retrouvent partout dans le monde dans le maïs et ses produits dérivés.
Benlashehr, Imad
core  

Evaluation of fertility toxicity and embryo-fetal developmental toxicity profile of Ayush AG, a compound herbo-mineral Ayurvedic formulation

Journal of Ayurveda and Integrative Medicine
Background: It is essential to generate the reproduction toxicity data of any drug that will be used in pregnancy or during the reproductive phase of life.
Shrirang B. Jamadagni, Mukul Tambe, M. Srinivasan, Sudesh Gaidhani, Goli Penchala Prasad, Sudhir Matte   +5 more
doaj   +1 more source