Results 111 to 120 of about 1,268,897 (251)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Advances in immunology of male reproductive toxicity induced by common environmental pollutants
Environment InternationalHumans are exposed to an ever-increasing number of environmental toxicants, some of which have gradually been identified as major risk factors for male reproductive health, even associated with male infertility.
Hao Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Analysis of the indicative value of repeated dose toxicity studies for reproductive toxicity
, 2022 S.S6-S7Assessment of reproductive toxicity is an animal-, time- and cost-consuming process. In order to refine, replace and reduce animal testing, the use of in-silico, in-vitro and alternative in-vivo strategies is tested for their value to predict ...
Lewin, Geertje +3 more
core
Materials Research ExpressMetallic nanoparticles (NPs) are used in various biomedical applications due to their widespread utility. This study compares the reproductive toxicity of chemically synthesized CuO NPs (ChemSyn CuO NPs) and green synthesized CuO NPs (GrSyn CuO NPs) in ...
Sania Naz +6 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Journal of Ayurveda and Integrative MedicineBackground: It is essential to generate the reproduction toxicity data of any drug that will be used in pregnancy or during the reproductive phase of life.
Shrirang B. Jamadagni +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
环境与职业医学This paper introduced the classification, sources, and human exposure status of synthetic antioxidants as emerging environmental pollutants, highlighting their widespread presence in human biological matrices, including urine, blood, adipose tissue, and ...
Weijia Xing, Tian Tian, Ying Wang
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source