Results 91 to 100 of about 1,022,108 (300)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A high throughput screening system for predicting chemically-induced reproductive organ deformities

, 2022
S.95-103There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret.
Buist, Harrie E., Vugt-Lussenburg, Barbara van, Kroese, Dinant E., Man, Hai-yen, Pieterse, Bart, Lewin, Geertje, Wolterbeek, Andre P.M., Rorije, Emiel, Linden, Sander C. van der, Piersma, Aldert H., Mangelsdorf, Inge, Burg, Bart van der   +11 more
core   +1 more source

Mechanisms of female reproductive toxicity in pigs induced by exposure to environmental pollutants

Molecules and Cells
: Environmental pollutants, including endocrine disruptors, heavy metals, nanomaterials, and pesticides, have been detected in various ecosystems and are of growing global concern.
Junho Park, Hojun Lee, Junhun Kweon, Sunwoo Park, Jiyeon Ham, Fuller W. Bazer, Gwonhwa Song   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Modulating Effects of L-Arginine and Tribulus terrestris Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Receptors, and Nitric Oxide Synthase Interplay

The protective potentials of Tribulus terrestris (TT) and L-arginine (L-Arg) against reproductive toxicity induced by fipronil (FPN) in male rats were investigated. A total of 36 male rats were allocated into six groups: control, TT, L-Arg, FPN, FPN + TT,
Ahmed A. Bakhashwain, Noran M. Tawfik, Ibrahim E. Helal, Heba M. A. Abdelrazek, Hatim A. Al-Abbadi, Menna Allah I. El-Menyawy, Heba N. Gad EL-Hak, Wafaa K. Teleb, Doaa H. Elsayed, Eman A. Ahmed   +9 more
core   +1 more source

The accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during the reproductive periods induces reproductive endocrine disorders in their offspring

Ecotoxicology and Environmental Safety
Microcystin-LR’s reproductive (reproductive and non-reproductive periods) and transgenerational toxicity in amphibians remains poorly understood. Adult Pelophylax nigromaculatus in reproductive and non-reproductive periods were exposed to MC-LR to ...
Huijuan Zhang, Yuefei Ruan, Zifang Ding, Zheng Li, Jun He, Jing Li, Pei Hong, Hailong Wu, Yilin Shu   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Direct and In-Utero Exposure to Quaternary Ammonium Disinfectants Alters Sperm Parameters and mRNA Expression of Epigenetic Enzymes in the Testes of Male CD-1 Mice

Quaternary ammonium compounds (QACs) are a class of chemicals used for their antimicrobial, surfactant, and antistatic properties. QACs are present in many consumer products, and people are regularly exposed to them. We have previously shown reproductive
Vanessa E. Melin, Terry C. Hrubec
core   +1 more source

Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate

, 2013
The review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins ...
Gabriela Carvalho Zamprogno, Ana Flavia Locateli Godoi, da Costa, Mércia Barcellos, Godoi, Ana Flavia Locateli, Mary Rosa Rodrigues de Marchi, Graceli, Jones Bernardes, Dayana Moscardi dos Santos, Sena, Gabriela Cavati, Marchi, Mary Rosa Rodrigues de, Jones Bernardes Graceli, Mércia Barcellos da Costa, Marcos Antonio dos Santos Fernandez, Lopes, Pedro Francisco Iguatemy, Gabriela Cavati Sena, Marchi, Mary Rosa Rodrigues de [UNESP], dos Santos Fernandez, Marcos Antonio, Pedro Francisco Iguatemy Lopes, Zamprogno, Gabriela Carvalho, dos Santos, Dayana Moscardi   +18 more
core   +1 more source

Ecotoxicology and ecophysiology of mysids, with special reference to copper toxicity in Praunus flexuosus

, 2000
Toxicity of dissolved copper was examined in a common coastal mysid population {Praunusflexuosus}. The life cycle and ecophysiology were studied under natural conditions throughout the year, and responses to dissolved copper were determined in the ...
Garnacho, Eva
core   +1 more source