Results 71 to 80 of about 1,268,897 (251)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Direct and In-Utero Exposure to Quaternary Ammonium Disinfectants Alters Sperm Parameters and mRNA Expression of Epigenetic Enzymes in the Testes of Male CD-1 Mice

Quaternary ammonium compounds (QACs) are a class of chemicals used for their antimicrobial, surfactant, and antistatic properties. QACs are present in many consumer products, and people are regularly exposed to them. We have previously shown reproductive
Vanessa E. Melin, Terry C. Hrubec
core   +1 more source

Evaluation of reproductive toxicity in rats treated with triclosan

, 2018
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq: 454499/2014-0Triclosan (TCS) is an antibacterial agent used in a variety of consumer products such as: soaps ...
Patricia Carvalho Garcia, Maria Luiza Marino de Góes, Pernoncini, Karine Vandressa, Gerardin, Daniela Cristina Ceccatto, Daniela Cristina Ceccatto Gerardin, Garcia, Patricia Carvalho, Bruno Garcia Montagnini, Montagnini, Bruno Garcia, Karine Vandressa Pernoncini, de Góes, Maria Luiza Marino, Garcia, Patricia Carvalho [UNESP]   +10 more
core   +1 more source

Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus). [PDF]

, 2018
OBJECTIVE: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced ...
Saleh, Ramadan, Agarwal, Ashok, Shrivastava, Vinoy K, Ahmad, Bashir, Henkel, Ralf   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ecotoxicology and ecophysiology of mysids, with special reference to copper toxicity in Praunus flexuosus

, 2000
Toxicity of dissolved copper was examined in a common coastal mysid population {Praunusflexuosus}. The life cycle and ecophysiology were studied under natural conditions throughout the year, and responses to dissolved copper were determined in the ...
Garnacho, Eva
core   +1 more source

Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system

Frontiers in Pharmacology
In recent years, the increasing number of infertility cases has led to a greater research focus on the reproductive toxicity of drugs due to the fact that some classes of pharmacotherapeutic agents have been found to exert deleterious effects on the ...
Yu Feng, Xiaoyan Qu, Hua Hao
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Micro/Nanoplastic Exposure on Placental Health and Adverse Pregnancy Risks: Novel Assessment System Based upon Targeted Risk Assessment Environmental Chemicals Strategy

Micro/nanoplastics (MNPs), as emerging pollutants, have been detected in both the maternal and fetal sides of the placenta in pregnant women, and their reproductive toxicity has been demonstrated in in vivo and in vitro experimental models.
Danyang Wan, Yujie Liu, Zhaofeng Liu, Beibei Gao, Quanquan Guan, Qianjing Chang, Qing Wang, Rui Niu, Yankai Xia   +8 more
core   +1 more source