Results 81 to 90 of about 1,268,897 (251)

Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate

, 2013
The review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins ...
Gabriela Carvalho Zamprogno, Ana Flavia Locateli Godoi, da Costa, Mércia Barcellos, Godoi, Ana Flavia Locateli, Mary Rosa Rodrigues de Marchi, Graceli, Jones Bernardes, Dayana Moscardi dos Santos, Sena, Gabriela Cavati, Marchi, Mary Rosa Rodrigues de, Jones Bernardes Graceli, Mércia Barcellos da Costa, Marcos Antonio dos Santos Fernandez, Lopes, Pedro Francisco Iguatemy, Gabriela Cavati Sena, Marchi, Mary Rosa Rodrigues de [UNESP], dos Santos Fernandez, Marcos Antonio, Pedro Francisco Iguatemy Lopes, Zamprogno, Gabriela Carvalho, dos Santos, Dayana Moscardi   +18 more
core   +1 more source

The research progress on the impact of antibiotics on the male reproductive system

Environment International
Antibiotics are extensively utilized in the livestock and poultry industry and can accumulate in animals and the environment, leading to potential health risks for humans via food and water consumption. Research on antibiotic toxicity, particularly their
Lirui Hou, Yuhan Fu, Chong Zhao, Lihong Fan, Hongbo Hu, Shutao Yin   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Screening and Mechanism Study of Three Antagonistic Drugs, Oxysophoridine, Rutin, and Phellodendrine, against Zearalenone-Induced Reproductive Toxicity in Ovine Oocytes

Antioxidants
Zearalenone (ZEN) is a common fungal toxin with reproductive toxicity in various grains. It poses a serious threat to ovine and other animal husbandry industries, as well as human reproductive health.
Zongshuai Li, Tian Ma, Yali Liu, Wanruo Liu, Xingxu Zhao, Gaiping Zhang, Jianlin Wang, Yong Zhang   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Mechanisms of female reproductive toxicity in pigs induced by exposure to environmental pollutants

Molecules and Cells
: Environmental pollutants, including endocrine disruptors, heavy metals, nanomaterials, and pesticides, have been detected in various ecosystems and are of growing global concern.
Junho Park, Hojun Lee, Junhun Kweon, Sunwoo Park, Jiyeon Ham, Fuller W. Bazer, Gwonhwa Song   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during the reproductive periods induces reproductive endocrine disorders in their offspring

Ecotoxicology and Environmental Safety
Microcystin-LR’s reproductive (reproductive and non-reproductive periods) and transgenerational toxicity in amphibians remains poorly understood. Adult Pelophylax nigromaculatus in reproductive and non-reproductive periods were exposed to MC-LR to ...
Huijuan Zhang, Yuefei Ruan, Zifang Ding, Zheng Li, Jun He, Jing Li, Pei Hong, Hailong Wu, Yilin Shu   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source