Results 31 to 40 of about 223,319 (331)

Development, validation and application of ERα- and PPARγ-mediated female reproductive toxicity prediction models based on adverse outcome pathway

open access: yesEcotoxicology and Environmental Safety
Traditional methods for reproductive toxicity assessment are insufficient for high-throughput chemical screening. Although efforts have been made in recent years to develop predictive models for reproductive toxicity, in-depth modeling of female-specific
Ya Tian   +8 more
doaj   +1 more source

Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production [PDF]

open access: yes, 1995
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
Albro P   +8 more
core   +2 more sources

Research progress on food-derived antioxidants for alleviating toxicity of endocrine disrupting chemicals

open access: yes环境与职业医学
Endocrine disrupting chemicals (EDCs) are a class of chemical substances widely present in daily-life environment, and can enter human body through various pathways, posing a threat to reproductive development and health.
Jiaxian CHEN, Maohua MIAO, Ziliang WANG
doaj   +1 more source

Impact of Endosulfan on Male Reproductive functions - a review [PDF]

open access: yesPerspectives In Medical Research, 2016
Endosulfan is an organochlorine insecticide and acaracide used to control a broad range of insect and arthropod pests on a wide variety of crops in many agrosystems. It can cause acute and chronic toxicity.
Srinivasa Jayachandra
doaj  

Proteomic Study on the Reproductive Toxicity of Tripterygium Glycosides in Rats

open access: yesFrontiers in Pharmacology, 2022
Tripterygium glycoside tablet (TGT) is a common clinically used and effective non-steroidal immunosuppressant. However, its reproductive toxicity limits its application in pediatric immune diseases, warranting the study of the molecular mechanism behind ...
Yanlin Dai   +7 more
doaj   +1 more source

Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]

open access: yes, 2008
TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III   +5 more
core   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale   +6 more
wiley   +1 more source

Reproductive toxicity study on water extract of flower of Dendrobium Devonianum Paxt.’s flower in SD rats

open access: yesZhongguo shipin weisheng zazhi, 2023
ObjectiveTo evaluate the reproductive toxicity of water extract of flower of Dendrobium devonianum Paxt.MethodsAccording to the reproductive toxicity evaluation from National Standard of the People’s Republic of China ‘Reproductive Toxicity Study’(GB ...
SHAO Naimin   +8 more
doaj   +1 more source

Review of QSAR Models and Software Tools for Predicting Developmental and Reproductive Toxicity [PDF]

open access: yes, 2010
This report provides a state-of-the-art review of available computational models for developmental and reproductive toxicity, including Quantitative Structure-Activity Relationship (QSARs) and related estimation methods such as decision tree approaches ...
LO PIPARO ELENA, WORTH Andrew
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy