Results 21 to 30 of about 1,268,897 (251)

Establishment Methods and Application Evaluation of Animal Models in Reproductive Toxicology Research

Shiyan dongwu yu bijiao yixue
Reproductive toxicology is a discipline that uses toxicological methods to study the mechanisms by which foreign substances interfere with the generation of eggs or sperm and their detrimental effects on offspring.
HUANG Dongyan, WU Jianhui
doaj   +1 more source

Development, validation and application of ERα- and PPARγ-mediated female reproductive toxicity prediction models based on adverse outcome pathway

Ecotoxicology and Environmental Safety
Traditional methods for reproductive toxicity assessment are insufficient for high-throughput chemical screening. Although efforts have been made in recent years to develop predictive models for reproductive toxicity, in-depth modeling of female-specific
Ya Tian, Liang Lyu, Hui-ming Yang, Yi Yang, Zheng Li, Yi-yuan Zeng, Hong-zhan Liu, Li-li Yang, Xiao-feng Zhang   +8 more
doaj   +1 more source

Research progress on food-derived antioxidants for alleviating toxicity of endocrine disrupting chemicals

环境与职业医学
Endocrine disrupting chemicals (EDCs) are a class of chemical substances widely present in daily-life environment, and can enter human body through various pathways, posing a threat to reproductive development and health.
Jiaxian CHEN, Maohua MIAO, Ziliang WANG
doaj   +1 more source

Impact of Endosulfan on Male Reproductive functions - a review [PDF]

Perspectives In Medical Research, 2016
Endosulfan is an organochlorine insecticide and acaracide used to control a broad range of insect and arthropod pests on a wide variety of crops in many agrosystems. It can cause acute and chronic toxicity.
Srinivasa Jayachandra
doaj  

The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review

Ecotoxicology and Environmental Safety, 2023
Arsenic toxicity is one of the most trending reasons for several malfunctions, particularly reproductive toxicity. The exact mechanism of arsenic poisoning is a big question mark. Exposure to arsenic reduces sperm count, impairs fertilization, and causes
Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan   +1 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Proteomic Study on the Reproductive Toxicity of Tripterygium Glycosides in Rats

Frontiers in Pharmacology, 2022
Tripterygium glycoside tablet (TGT) is a common clinically used and effective non-steroidal immunosuppressant. However, its reproductive toxicity limits its application in pediatric immune diseases, warranting the study of the molecular mechanism behind ...
Yanlin Dai, Lihui Sun, Shanshan Han, Shanshan Han, Shanshan Xu, Long Wang, Ying Ding, Ying Ding   +7 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source