Results 41 to 50 of about 219,005 (309)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice

Toxicology Reports, 2015
6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral gavage to CD-1 mice as a suspension in 0.5% aqueous methylcellulose with 0.1% Tween-80 at dosages
Pushkor Mukerji, Jessica Caverly Rae, Robert C. Buck, John C. O’Connor   +3 more
doaj   +1 more source

Leveraging Epidemiology to Improve Risk Assessment. [PDF]

, 2011
The field of environmental public health is at an important crossroad. Our current biomonitoring efforts document widespread exposure to a host of chemicals for which toxicity information is lacking.
Burke, Thomas A, Fox, Mary A, Nachman, Keeve E, Rodricks, Joseph V, Sheehan, Mary C, Woodruff, Tracey J   +5 more
core  

Cryopreservation of equine oocytes: looking into the crystal ball [PDF]

, 2020
In vitro embryo production has evolved rapidly in the horse over the past decade, but blastocyst rates from vitrified equine oocytes remain quite poor and further research is needed to warrant application.
Angel Velez, Daniel, De Coster, Tine, Smits, Katrien, Van Soom, Ann, Woelders, Henri   +4 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Convenient screening of the reproductive toxicity of favipiravir and antiviral drugs in Caenorhabditis elegans

Heliyon
Reproductive toxicity is one of the major concerns in drug development. Thus, we have developed its screening system using Caenorhabditis elegans, which has a life cycle of three days and similar coding genes as humans.
Kimiyasu Shiraki, Mizuki Mishima, Noriaki Sato, Yasuo Imoto, Kiyoji Nishiwaki   +4 more
doaj   +1 more source

Acute and Reproductive Toxicity Evaluation of Ormona^® SI and Ormona^® RC—Two New Nutraceuticals with Geranylgeraniol, Tocotrienols, Anthocyanins, and Isoflavones—In Adult Zebrafish

Pharmaceuticals, 2022
The zebrafish is a popular organism to test the toxicity of compounds. Here, we evaluate the acute and reproductive toxicity of Ormona SI® (OSI) and RC® (ORC), two herbal products developed for menopausal women with tocotrienols, geranylgeraniol ...
Clarice Flexa da Rocha, Camila de Nazaré Nunes Flexa, Gisele Custodio de Souza, Arlindo César Matias Pereira, Helison de Oliveira Carvalho, Aline Lopes do Nascimento, Natasha Juliana Perdigão de Jesus Vasconcelos, Heitor Ribeiro da Silva, José Carlos Tavares Carvalho   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Dental amalgam fillings: An under-investigated source of mercury exposure [PDF]

, 2019
Dental amalgam fillings, which contain about 50% mercury, have been used since the early 19th century. However, their use has been controversial, particularly because they continually release small amounts of mercury.
Ahlqwist, Ahlqwist, Ahlqwist, Bailer, Bangsi, Barregard, Barregard, Barregard, Bates, Bellinger, Bellinger, Bellinger, Bjorkman, Bjørklund, Boyd, Bratel, Bratel, Casetta, Clarkson, Clarkson, Counter, Daniels, de Burbure, DeRouen, Dye, Eti, Factor-Litvak, Ganss, Goldwater, Gun, Herrstrom, Herrstrom, Herrstrom, Herrstrom, Hsu, Hujoel, Hyson, Kingman, Lund, Malt, McGrother, Melchart, Nylander, Rothwell, Sandborgh-Englund, Saxe, Saxe, Schuurs, Seidler, Siblerud, Siblerud, Siblerud, Soler, Sun, Woods, World Health Organization   +55 more
core   +1 more source

Reproductive Toxicity of Environmental Agents [PDF]

Annual Review of Public Health, 1982
Reproductive processes may be affected adversely by exposure to certain levels of environmental agents, in both animals and humans. It is not only exposure during pregnancy itself that may be hazardous, but exposure of males and females to some environmental agents at any time may cause changes in the germ cells; this can result in infertility or an ...
K S, Rao, B A, Schwetz
openaire   +2 more sources