Results 211 to 220 of about 175,723 (295)

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

The Role of Pattern Recognition Receptors in Epigenetic and Metabolic Reprogramming: Insights into Trained Immunity. [PDF]

J Inflamm Res
Li Y, Chen M, Li J, Hu J.
europepmc   +1 more source

HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

, 2004
Kyra Oswald‐Richter, Stacy M. Grill, Nikki W. Shariat, Mindy Leelawong, Mark S. Sundrud, David W. Haas, Derya Unutmaz   +6 more
openalex   +2 more sources

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Editorial: Biomimetics and immuno-informed biomaterials: a functional role in immune response and <i>in vivo</i> reprogramming. [PDF]

Front Immunol
Kaity S, Singh M, Govindappa PK, Paul MK, Roy S.   +4 more
europepmc   +1 more source

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu   +10 more
wiley   +1 more source

Leveraging cardiac reprogramming with CRISPRa-SAM technology. [PDF]

Mol Ther Nucleic Acids
Borthakur A, Venugopal KN, Thummer RP.
europepmc   +1 more source

Nuclear Reprogramming by Human Embryonic Stem Cells [PDF]

, 2005
M. Azim Surani
openalex   +1 more source

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

Advanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao, Yijia Yin, Fangyuan Shuai, Waishan Lam, Tao Zhou, Yaxin Xie, Xuesong He, Xianglong Han   +7 more
wiley   +1 more source

Competing dynamic gene regulatory networks involved in fibroblast reprogramming to hematopoietic progenitor cells. [PDF]

Stem Cell Reports
Shafiq S, Hamashima K, Guest LA, Al-Anbaki AH, Amaral FMR, Wiseman DH, Kouskoff V, Lacaud G, Loh YH, Batta K.   +9 more
europepmc   +1 more source