Results 261 to 270 of about 358,538 (335)

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Redefining cellular reprogramming with advanced genomic technologies. [PDF]

Nat Rev Genet
Morris SA.
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Correction: Early inhibition of BRD4 facilitates iPSC reprogramming via accelerating rDNA dynamic expression. [PDF]

BMC Biol
Zhang Z, Hu X, Sun Y, Lei L, Liu Z.
europepmc   +1 more source

Three-dimensional cell-cell interactions promote direct reprogramming of patient fibroblasts into functional and transplantable neurons

Janko Kajtez, Kerstin Laurin, Fredrik Nilsson, Andreas Bruzelius, Efraín Cepeda-Prado, Marcella Birtele, Roger A. Barker, Freja Herborg, Daniella Rylander Ottosson, Petter Storm, Alessandro Fiorenzano, Mette Habekost, Malin Parmar   +12 more
openalex   +1 more source

Reprogramming the cortex

Journal of Biosciences, 2000
openaire   +2 more sources

Evolution and the Embryo: The Evidence for Special Creation [PDF]

, 2007
Mauceri, Joseph M.
core   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Overexpression of the pioneer transcription factor Nr5a2 promotes the development of mouse somatic cell nuclear transfer embryos. [PDF]

PLoS Biol
Zhao Y, Zhang M, You Y, Zhang J, Ji Y, Lei L.   +5 more
europepmc   +1 more source