Results 281 to 290 of about 358,538 (335)

Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration

Alessandro Cutilli, Suze A. Jansen, Francesca Paolucci, Marliek van Hoesel, Cynthia L Fredericks, Tessa A M Mulder, Theofilos Chalkiadakis, Michal Mokrý, Stefan Preković, Enric Mocholí, Caroline A. Lindemans, Paul J. Coffer   +11 more
openalex   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Decoding cardiac metabolic reprogramming through single-cell multi-omics: from mechanisms to therapeutic applications. [PDF]

Front Cell Dev Biol
Rong W, Zhou Y.
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Coactivator networks orchestrating noncanonical AR programs in enzalutamide-resistant CRPC. [PDF]

Front Oncol
Gardner EJ, Ponnusamy S, Adelaiye-Ogala R.   +2 more
europepmc   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Correction for Wang et al., Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Activation of canonical Wnt signaling is required for efficient direct reprogramming into human hepatic progenitor cells. [PDF]

Stem Cell Reports
Miura S, Horisawa K, Inada H, Sakaguchi Y, Yorino M, Suzuki A.   +5 more
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective. [PDF]

Immunol Rev
Boden KA, Chai J, Kufazvinei TTJ, Choudhury RP.   +3 more
europepmc   +1 more source