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Critical Reviews in Biochemistry and Molecular Biology, 2012
Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation.
Ehrensberger AH, Svejstrup JQ
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Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation.
Ehrensberger AH, Svejstrup JQ
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Science, 2017
Prostate cancer cells alter identity to resist ...
Steven P. Balk, Kathleen Kelly
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Prostate cancer cells alter identity to resist ...
Steven P. Balk, Kathleen Kelly
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Regeneration and reprogramming
Current Opinion in Genetics & Development, 2012Recent reprogramming studies indicate that mammalian, somatic cells have the potential to achieve pluripotent states and undergo cell type switching. Such cellular traits are observed under natural conditions in animals that regenerate complex organs. A number of invertebrates display the amazing trait of whole body regeneration.
Dunja Knapp, Elly M. Tanaka
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Current Opinion in Genetics & Development, 2012
C5 - Other Refereed Contribution to Refereed ...
Pera, MF, Plath, K
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C5 - Other Refereed Contribution to Refereed ...
Pera, MF, Plath, K
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Reprogramming in nuclear transfer
Current Opinion in Genetics & Development, 2003Reprogramming a nucleus by transferring it to oocyte cytoplasm triggers epigenetic changes that eventually lead to the restoration of a totipotent state and the birth of a viable animal. A simplified way of studying this complex process is to study cell hybrids.
Jouneau, Alice, Renard, Jean Paul
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2004
Publisher Summary Developmental biologists began to consider whether all nuclei could be reprogrammed and become totipotent in nuclear transfer experiments. From many subsequent experiments, it became clear that the maternally inherited factors contained within the oocyte also have the extraordinary property to restore totipotency to a differentiated ...
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Publisher Summary Developmental biologists began to consider whether all nuclei could be reprogrammed and become totipotent in nuclear transfer experiments. From many subsequent experiments, it became clear that the maternally inherited factors contained within the oocyte also have the extraordinary property to restore totipotency to a differentiated ...
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2006
The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
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The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
openaire +2 more sources