Results 41 to 50 of about 238,286 (345)
World Journal of Stem Cells, 2015 Induced pluripotent stem cells (iPSCs) have been the focal point of ever increasing interest and scrutiny as they hold the promise of personalized regenerative medicine. However, creation of iPSCs is an inefficient process that requires forced expression of potentially oncogenic proteins.
Melissa Popowski, Haley Tucker
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Obesity as a Neuroendocrine Reprogramming [PDF]
Medicina, 2021 Obesity represents a health problem resulting from a broken balance between energy intake and energy expenditure leading to excess fat accumulation. Elucidating molecular and cellular pathways beyond the establishment of obesity remains the main challenge facing the progress in understanding obesity and developing its treatment.
Abdelaziz Ghanemi +2 more
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LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer
Cancer Communications, 2020 Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However,
Yue Tan +5 more
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Cell Communication and Signaling, 2022 Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma +10 more
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The Journal of Reproduction and Development, 2019 Historically, it had been widely accepted that the female mammalian ovary contained a limited number of oocytes that would reduce over time, without the possibility of replenishment. However, recent studies have suggested that female germline stem cells (
Huy-Hoang NGUYEN +4 more
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Multiplexed promoterless gene expression with CRISPReader
Genome Biology, 2019 Background Genes are comprised of DNA codes and contain promoters and other control elements for reading these codes. The rapid development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has made possible the ...
Hengji Zhan +5 more
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Algorithm for cellular reprogramming [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Reprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the concept of data-guided control in building a universal algorithm for directly reprogramming any human cell type into any other type ...
Scott Ronquist +9 more
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The Journal of Reproduction and DevelopmentIn vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE +6 more
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Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
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Signal Transduction and Targeted Therapy, 2020 Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.
Enli Yang +5 more
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