Results 81 to 90 of about 1,511,705 (293)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Towards a methodology for rigorous development of generic requirements patterns

open access: yes, 2005
We present work in progress on a methodology for the engineering, validation and verification of generic requirements using domain engineering and formal methods.
Johnson, Ian   +2 more
core  

Space education: Deriving benefits from industrial consortia [PDF]

open access: yes, 1993
As the number of spacefaring nations of the world increases, so does the difficulty of competing in a global economy. The development of high technology products and services for space programs, and the economic exploitation of these technologies for ...
Page, John R., Stone, Barbara A.
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Conceptual UX-aware Model of Requirements

open access: yes, 2016
User eXperience (UX) is becoming increasingly important for success of software products. Yet, many companies still face various challenges in their work with UX.
Feldt, Robert   +3 more
core   +2 more sources

User-centered requirement engineering for accessible chats in m-learning [PDF]

open access: yes, 2014
Chat applications are useful synchronous tools in mobile learning (m-learning) environments. However, these tools have accessibility problems which cannot be avoided by students and teachers with disabilities.
Calvo, Rocío   +2 more
core   +4 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Scenario driven requirement engineering for design and deployment of mobile communication networks [PDF]

open access: yes
The numbers of users and usage of mobile data service are increasing dramatically due to the introduction of smartphones and mobile broadband dongles. For the next decade the mobile broadband market is expected to grow and reach a level where the average
Beckman, Claes   +3 more
core  

Deep speckle correlation: a deep learning approach toward scalable imaging through scattering media [PDF]

open access: yes, 2018
Imaging through scattering is an important yet challenging problem. Tremendous progress has been made by exploiting the deterministic input–output “transmission matrix” for a fixed medium.
Li, Yunzhe, Tian, Lei, Xue, Yujia
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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