Results 61 to 70 of about 160,180 (288)

Research Data Alliance (RDA) and the Social Sciences

open access: yes, 2021
The Research Data Alliance (RDA, www.rd-alliance.org) is an international organization aiming to develop infrastructure and community activities that enable open sharing of data. The RDA operates across the globe and connects research data experts (like researchers, data stewards, librarians and funders) from a variety of disciplines, including the ...
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Impact of Partner Fit and Conflict Management on Alliance Performance In Indonesian Construction Companies

open access: yesJournal of Business and Social Review in Emerging Economies, 2015
Objective: The purpose of this paper is to investigate the alliance performance of construction companies. A conceptual model is proposed where alliance performance is influenced by a two-dimensional construct composed of the partner fit and conflict ...
Dicky Hida Syahchari   +2 more
doaj   +1 more source

The Role of Religious Centers in Building Solidarity Among Citizens with Social Capital Approach (Case Study: Ferdowsi-eh City - Shahryar Town) [PDF]

open access: yesجغرافیای اجتماعی شهری, 2017
In the present urbanization, especially in developing societies which­ lack of trust and isolation affected the lives of the majority of citizens, efforts for social alliance and raising social capital in the cities are of most important ­ goals of ...
Ali Shamsoddini, Meysam Rezayi
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

SCGAN-enhanced surrogate modeling for FEM analysis of induction motors: A practical use case

open access: yesResults in Engineering
Surrogate modeling is a powerful approach for industrial applications that provides data-driven approximations of complex physical or numerical simulators in exchange for minimal computational cost.
Unai Salaberria-Flaño   +4 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas   +18 more
wiley   +1 more source

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