Results 91 to 100 of about 40,886,999 (373)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Striking a Balance between Program Requirements and GT Principles

open access: yesGrounded Theory Review: An International Journal, 2009
Glaser’s term “compromised GT proposal” (2001, p.114) refers to the type of Grounded Theory (GT) proposal that is written in order to conform to the requirements of a standardized qualitative research proposal.
Sherry L. Xie
doaj  

Management of multi-method engineering design research: a case study [PDF]

open access: yes, 2002
There is a need for a research management methodology that will utilise research methods on an individual basis and when combined in a multi-method approach.
Al-Salka   +9 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Demystifying Theoretical Sampling in Grounded theory Research

open access: yesGrounded Theory Review: An International Journal, 2009
Theoretical sampling is a central tenet of classic grounded theory and is essential to the development and refinement of a theory that is ‘grounded’ in data.
Jenna Breckenridge, Derek Jones
doaj  

Designing a precision-medicine platform trial to improve the nutritional care and intestinal health of very preterm babies: the COLLABORATE study

open access: yesEfficacy and Mechanism Evaluation
Background Nutrition is essential for preterm brain development. Optimal nutrition is dependent upon gastrointestinal health. Primary objective To form a multiprofessional collaboration to design the world’s first neonatal precision-medicine platform ...
Neena Modi   +17 more
doaj   +1 more source

Design Fiction Diegetic Prototyping: A Research Framework for Visualizing Service Innovations [PDF]

open access: yes, 2019
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Purpose: This paper presents a design fiction diegetic prototyping methodology and research framework for ...
Belk, Russell   +2 more
core   +1 more source

Why emerging leaders should focus on being good postdoctoral supervisors

open access: yesFEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski   +5 more
wiley   +1 more source

Capacity Building in Research on Traditional Medicine: Experience of a Workshop Conducted under the Aegis of the Indian Council of Medical Research [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Training healthcare professionals in research methodology is essential to promote research and innovation. This is particularly relevant in India, where there is a wealth of potential drug candidates from Indian Traditional Medicine (TM) systems that ...
Padmaja Anil Marathe   +5 more
doaj   +1 more source

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