Results 101 to 110 of about 4,766,757 (295)

The need for a change in medical research thinking. Eco-systemic research frames are better suited to explore patterned disease behaviors

open access: yesFrontiers in Medicine
Many practicing physicians struggle to properly evaluate clinical research studies – they either simply do not know them, regard the reported findings as ‘truth’ since they were reported in a ‘reputable’ journal and blindly implement these interventions,
Joachim P. Sturmberg   +4 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Review: Giampietro Gobo (2008). Doing Ethnography

open access: yesForum: Qualitative Social Research, 2010
Doing Ethnography, by Giampietro GOBO, provides an introduction into ethnography from a practice perspective. The author discusses central topics, definitions, procedures, and reflections on the research process.
Stefan Thomas
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Review Essay: Encouraging Students to Think About Research as a Process

open access: yesForum: Qualitative Social Research, 2002
In Research Design in Social Research, David DE VAUS presents a wonderful opportunity for research design students and practitioners to think more about the planning and process of research design.
Mark A. Earley
doaj  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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