Results 81 to 90 of about 7,775,610 (280)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Web crawler research methodology [PDF]

In economic and social sciences it is crucial to test theoretical models against reliable and big enough databases. The general research challenge is to build up a well-structured database that suits well to the given research question and that is cost ...
Nemeslaki, András, Pocsarovszky, Károly   +1 more
core  

Research methodology in global strategy research [PDF]

, 2017
We review advances in research methodology used in global strategy research and provide suggestions on how researchers can improve their analyses and arguments.
Alcácer, Basile, Belderbos, Belderbos, Bertrand, Bowen, Cantwell, Castellani, Caves, Chang, Coombs, Cuervo-Cazurra, Dahl, Hennart, Hensher, Hitt, Levy, Montgomery, Mudambi, Peterson, Piscitello, Rugman, Rumelt, Schmidheiny, Shaver, Tallman, Tallman, Wu   +27 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Evaluation of interventions for informed consent for randomised controlled trials (ELICIT) : protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey [PDF]

, 2015
Acknowledgements This work was supported by personal fellowship award (to KG) from the Medical Research Council’s Strategic Skills Methodology programme.
Campbell, Marion K, Entwistle, Vikki, Fraser, Cynthia, Gillies, Kate, Treweek, Shaun P, Williamson, Paula R   +5 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Barriers to Early Breast Cancer Diagnosis in Sudanese Women Before the War

Breast Cancer: Targets and Therapy
Hana Eltayeb Salih Elamin,1 Hind Eltayeb Salih Elamin,2 Ghada Omer Hamad Abd El-Raheem,3 Mounkaila Noma1 1High Diploma in Research Methodology and Biostatistics, University of Medical Sciences and Technology UMST, Khartoum City, Khartoum State, Sudan ...
Elamin HES, Elamin HES, Abd El-Raheem GOH, Noma M   +3 more
doaj  

Narrative Research Methodology in Mobile Work Research [PDF]

, 2011
This book review provides a summary of the content of the book Mobile Work, Mobile Lives: Cultural Accounts of Lived Experiences and a critical review of the methodological strengths of the articles included in the book.
Jin, Li
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

On the methodology of management research [PDF]

Epistemology, methodology or philosophy of science, i.e., the foundations and validity of knowledge, have never been very popular subjects as applied to management research.
Rosanas, Josep M.
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