Results 81 to 90 of about 5,285,257 (310)

Pipeline Programs [PDF]

, 2017
Pipeline programs are designed to prepare and inspire students to pursue careers in medicine and medical research. SKMC is committed to providing experiences and education to middle school, high school, college, and graduate students from groups ...

core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Postpartum women’s prospective acceptability of long-acting HIV prevention approaches in Kenya: a qualitative study

BMC Health Services Research
Background New long-acting pre-exposure prophylaxis (LA-PrEP) options offer an alternative to daily oral PrEP, which poses difficulties for adherence, especially during pregnancy and postpartum.
Tessa Concepcion, John Kinuthia, Felix Abuna, Eunita Akim, Helen Aketch, Laurén Gómez, Grace John-Stewart, Bih Moki Suh, Emmaculate M Nzove, Nancy Ngumbau, Jerusha N Mogaka, Sarah Obatsa, Ben O Odhiambo, Caroline Omom, Marin Strong, Anjuli D Wagner, Salphine Watoyi, Jillian Pintye   +17 more
doaj   +1 more source

Measuring the Performance of Livability Programs, MTI Report 12-06 [PDF]

, 2013
This report analyzes the performance measurement processes adopted by five large “livability” programs throughout the United States. It compares and contrasts these programs by examining existing research in performance measurement methods.
Fabish, Lisa, Haas, Peter J.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

ECONOMIC RESEARCH PROGRAMS FOR COMMUNITY DEVELOPMENT--WHY DO IT? [PDF]

Community/Rural/Urban Development,
Motes, William C.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Locus-specific LINE-1 expression in clinical ovarian cancer specimens at the single-cell level

Scientific Reports
Long interspersed nuclear elements (LINE-1s/L1s) are a group of retrotransposons that can copy themselves within a genome. In humans, it is the most successful transposon in nucleotide content. L1 expression is generally mild in normal human tissues, but
Anna Perkiö, Barun Pradhan, Fatih Genc, Anna Pirttikoski, Sanna Pikkusaari, Erdogan Pekcan Erkan, Matias Marin Falco, Kaisa Huhtinen, Sara Narva, Johanna Hynninen, Liisa Kauppi, Anna Vähärautio   +11 more
doaj   +1 more source

MICHIGAN APPLE COMMITTEE WINTER 2003 GROWER SURVEY: RESEARCH PROGRAMS [PDF]

Crop Production/Industries,
Aguilar, Cristobal, Thornsbury, Suzanne
core   +1 more source

Implementation of Diversity Management Programs in Public Organizations: Lessons from Policy Implementation Research [PDF]

, 2005
The U.S. workforce is becoming more diverse, particularly in the public sector. As a result, a number of public-sector employers have initiated diversity management programs aimed to assist different types of employees in their needs at work.
David W. Pitts
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