Results 121 to 130 of about 10,605,669 (311)

Giving voice to equitable collaboration in participatory design [PDF]

, 2007
An AHRC funded research project titled Experimenting with the Co-experience Environment (June 2005 – June 2006) culminated in a physical environment designed in resonance with a small group of participants.
Ivey, Marlene, Kirk, Elizabeth, Li, Yue, O'Connor, Mark, Ricketts, Ian, Sanders, Elizabeth B.-N., Stevenson, Lorna   +6 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

When we talk about time, we mean many different things: employing visual mapping to think through more-than-human temporalities in participatory design

Frontiers in Communication
In recent years, the scope of participatory design has broadened to encompass perspectives and approaches beyond the human realm. This expansion requires considering multiple aspects to fully capture ‘more-than-humans’ diversity and concerns.
Hadas Zohar, Luca Simeone, Amalia de Götzen, Nicola Morelli   +3 more
doaj   +1 more source

Empirical research through design

, 2009
This paper describes the empirical research through design method (ERDM), which differs from current approaches to research through design by enforcing the need for the designer, after a series of pilot prototype based studies, to a-priori develop a number of testable interaction design hypothesis which are then embedded in a working prototype and ...
Keyson, D.V., Bruns, M.
openaire   +1 more source

Facilitators and Barriers to the Integration of Healthcare Service and Building Design [PDF]

Service design research recognises the importance of infrastructure design in the achievement of streamlined service delivery. Although research about service design and building design is abundant, very little is known about the integration of these ...
Codinhoto, Ricardo, Kagioglou, Mike, Koskela, Lauri, Rooke, John, Tzortzopoulos, Patricia   +4 more
core  

Inclusive design and making in practice: Bringing bodily experience into closer contact with making

, 2018
This paper develops our understanding of the nature of inclusive design, first through critique of controversies that to some degree downplay inclusive design as a distinct design movement.
Luck, Rachael
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sharing the vision:representing the matters of concern for design-led fledgling companies in Scotland [PDF]

, 2016
Design is being performed on an ever-increasing spectrum of complex practices arising in response to emerging markets and technologies, co-design, digital interaction, service design and cultures of innovation.
Galloway, Dayna, Johnson, Michael Pierre, Prior, Suzanne, White, Gregor   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

2D3D2D: a diagnostic approach to textile and fashion research practice [PDF]

, 2010
In the School of Art and Design, at Nottingham Trent University, a range of research methods and practices have developed through PhD and post doctoral study in relation to printed textile design and new technology.
Briggs-Goode, A, Northall, C, Townsend, K   +2 more
core