Results 131 to 140 of about 10,605,669 (311)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plant pixel: An optimized bio-inspired living wall system

Developments in the Built Environment
Current Modular Living Wall Systems (MLWS) have many benefits but are often also characterized by high costs, high-embodied carbon and short life span materials. To address these issues a bio-inspired MLWS prototype was developed: Plant Pixel.
Maricruz Solera Jimenez, João Cortesão, Sanda Lenzholzer, Ralf Walker   +3 more
doaj   +1 more source

Project report. A subtropical urban community, investigating medium to high density residential typologies by Design Charrette [PDF]

, 2009
The Centre for Subtropical Design at QUT, in partnership with the Queensland Government and Brisbane City Council, conducts research focused on 'best practice' outcomes for higher density urban living environments in the subtropics through the study of ...
Kennedy, Rosemary
core   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

What Research through Art can bring to CSCW: exploring ambiguous futures of work

i-com
As work is shifting and changing, we, CSCW researchers, must consider our role in creating work futures, and what experiences we want to produce through technology design. What qualities are important to consider about the human experience when designing
Dunn Kellie, Shklovski Irina, Bjørn Pernille   +2 more
doaj   +1 more source

Operationalising “loveability”: an interdisciplinary approach to enriching quality of life experiences in cities through creative cultural spaces

Frontiers in Built Environment
Loveability represents an emerging answer for enriching urban quality of life. The idea prioritises city dwellers’ emotional connections with psycho-spatial aspects of cities, beyond mere infrastructure, functionality, or services (“liveability”), which ...
Mizan Rambhoros, Raymond Richard Neutra, Rosa Cerarols, Matthew Pelowski   +3 more
doaj   +1 more source

Structuring Roles in Research Through Design Collaboration

Proceedings of DRS, 2018
In Research through Design knowledge is generated, but not always captured and shared effectively. When working in a multidisciplinary team of, e.g. designers, design researchers, academic researchers and domain practitioners confusion about roles, processes, and results easily occurs.
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Research through Design: a Camera Case Study [PDF]

, 2007
Information-for-use has become abstracted from human skills during the rise of interactive products. This chapter describes the search for a new interaction paradigm for interactive products, applying a research through design approach. Five conceptual cameras were designed to explore the solution domain for this new paradigm, named rich interaction ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source