Results 81 to 90 of about 726,944 (258)

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Margin status after laparoscopic resection of colorectal liver metastases: does a narrow resection margin have an influence on survival and local recurrence? [PDF]

, 2014
ObjectivesRecent studies of margin-related recurrence have raised questions on the necessity of ensuring wide resection margins in the resection of colorectal liver metastases.
Postriganova, Nadya, Røsok, Bård I., Barkhatov, Leonid, Fretland, Åsmund A., Edwin, Bjørn, Kazaryan, Airazat M.   +5 more
core   +1 more source

Evaluation of Resection Margin after Image-Guided Dural Tail Resection in Convexity Meningiomas

, 2021
Infiltration of adjacent dura with meningioma cells is a common phenomenon. Wide resection of the dural tail (DT) to achieve a gross total resection is a general recommendation.
Florian Ringel, Darius Kalasauskas, Naureen Keric, Clemens J. Sommer, Yasemin Tanyildizi, Mirjam Renovanz, Marc A. Brockmann   +6 more
core   +1 more source

Revising the definition of vertical margin involvement following endoscopic polypectomy may reduce unnecessary surgery in patients with malignant colorectal polyps

JGH Open, 2020
Background and Study Aims Endoscopically resected malignant colorectal polyps (MCPs) present a dilemma regarding whether the risk of residual disease justifies a major bowel resection.
Colin Richards, Priyanthi Kumarasinghe, Hannah Hessamodini, Alice Waldron, Diharah Fernando, Rupert Hodder, Angela Jacques, Spiro Raftopoulos   +7 more
doaj   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

The Mesopancreas remains at risk in primary resectable pancreatic cancer patients: time to reappraise resectability criteria?

Cancer Treatment and Research Communications
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with poor survival, and complete surgical resection with a negative circumferential resection margin (R0CRM–) remains the only potentially curative treatment.
Stephan O. David, Andrea Alexander, Farid Ziayee, Ahmad B. Sultani, Christoph Roderburg, Irene Esposito, Lena Haeberle-Graser, Sascha Vaghiri, Wolfram T. Knoefel, Sami A. Safi   +9 more
doaj   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

The Impact of KRAS Status on the Required Surgical Margin Width for Colorectal Liver Metastasis Resection

, 2023
Local recurrence after colorectal liver metastasis (CRLM) resection severely affects survival; however, the required surgical margin width remains controversial.
Koji Kitamura, Tatsuya Koyama, Kenji Uryuhara, Kai Nakao, Kentaro Iwaki, Satoshi Kaihara, Shotaro Matsuda, Nobu Oshima, Masato Kondo, Kan Toriguchi, Hiroki Hashida, Hiroyuki Kobayashi   +11 more
core   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Significance of resection margin in hepatectomy for hepatocellular carcinoma: A critical reappraisal

, 1999
Objective: To evaluate the influence of the width and histologic involvement of the resection margin on postoperative recurrence after resection of hepatocellular carcinoma (HCC).
Wong, J, Fan, ST, Poon, RTP, Ng, IOL
core   +1 more source