Results 91 to 100 of about 726,944 (258)

Structured Cap-assisted Margin Assessment Reduces Residual Neoplasia after Colorectal Polypectomy: A Prospective Multicentre Proof-of-Concept Study

Endoscopy International Open
Background and study aims Recurrence after endoscopic resection of medium-to-large non-pedunculated colorectal polyps remains common and varies substantially between operators.
Alexander Huelsen, Timothy Willis, Prabha Ketheson, Caroline Cooper, Jennifer Borowsky, Sooraj Pillay, Ian Paul Hughes, Zaki Hamarneh   +7 more
doaj   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Accuracy evaluation of preoperative indocyanine green tattooing and intraoperative colonoscopy in determining surgical resection margins for left-sided colorectal cancer: a retrospective study in Korea

Journal of Minimally Invasive Surgery
Purpose: We aimed to evaluate the precision of preoperative colonoscopic tattooing and intraoperative colonoscopic tumor localization in determining distal surgical margins for left-sided colorectal cancer surgery.
Byung-Soo Park, Sung Hwan Cho, Gyung Mo Son, Hyun Sung Kim, Jin Ook Jang, Dae Gon Ryu, Su Jin Kim, Su Bum Park, Hyung Wook Kim   +8 more
doaj   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Margin Requirements with Intraday Dynamics [PDF]

Both in practice and in the academic literature, models for setting margin requirements in futures markets use daily closing price changes. However, financial markets have recently shown high intraday volatility, which could bring more risk than expected.
Francois Longin, John Cotter
core  

A positive proximal resection margin is associated with anastomotic complications following primary ileocaecal resection for Crohn's disease

, 2019
Purposes: Bowel resection in patients with Crohn's disease (CD) has a high reported rate of postoperative complications and surgical recurrence. A macroscopically normal resection margin is recommended in CD surgery as wider margins do not translate in ...
Lucarini A, Celentano V, Garofalo E, Flashman KG   +3 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Tumor-positive margin and IVIS image after partial tumor resection.

, 2015
(A) Histological Image of the resected tumor from mouse S5 with tumor-positive margin. (B) IVIS image of three different mice two weeks after receiving a tumor resection. The IVIS image from mouse S4 shows a positive bioluminescent signal in the previous
Mustafa Sarimollaoglu (133123), Mazen A. Juratli (795110), Yulian A. Menyaev (795113), Dmitry A. Nedosekin (795111), James Y. Suen (795114), Eric R. Siegel (51918), Azemat Jamshidi-Parsian (787995), Chengzhong Cai (795112), Ekaterina I. Galanzha (133115), Vladimir P. Zharov (133143)   +9 more
core   +1 more source

Preoperative Chemotherapy and Resection Margin Status in Colorectal Liver Metastasis Patients: A Propensity Score-Matched Analysis [PDF]

, 2019
In this article, we compared the early and long-term outcomes of patients with metastatic colorectal cancer treated with chemotherapy followed by resection with those of patients undergoing surgery first, focusing our analysis on resection margin status.
D'Acapito, Fabrizio, La Barba, Giuliano, Gardini, Andrea Casadei, Gardini, Andrea, Mirarchi, Maria Teresa, Frassineti, Giovanni L, Solaini, Leonardo, Ercolani, Giorgio, Passardi, Alessandro, Casadei Gardini, Andrea, Cucchetti, Alessandro, Cucchi, Michele   +11 more
core   +1 more source