Results 161 to 170 of about 5,765,787 (386)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Study on residual stress and strain during rail rolling contact of straight U75V rail

Metalurgija, 2019
The distribution of residual stress produced by straightening process in side the rail is obtained. And then the residual stress result is used as the initial condition to study the stress and strain variation rule of wheel-rail rolling contact process ...
M. X. Gao, H. Song, J. Yang, L. J. Fu
doaj  

Study on Residual Stress in Single-sided and Double-sided Friction Stir Welding of Thick Plate 2219 Aluminum Alloy

Yuanzineng kexue jishu
Welding residual stress is related to the mechanical properties and service life of components. To accurately grasp the residual stress distribution of thick plate 2219 aluminum alloy after friction stir welding (FSW), optimize the welding process, and ...
WANG Binrong
doaj   +1 more source

Residual Stress in Wheels: Comparison of Neutron Diffraction and Ultrasonic Methods, with Trends in RCF [PDF]

, 2014
The critical damage mechanism on many GB passenger train wheels is Rolling Contact Fatigue (RCF) cracking in the rim. Evidence from field observations suggests that RCF damage occurs much more quickly as the wheelsets near the end of their life.
Bevan, Adam, Kabra, S, Molyneux-Berry, Paul, Zhang, S. Y   +3 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Effect of shot peening on surface fatigue life of carburized and hardened AISI 9310 spur gears [PDF]

Surface fatigue tests were conducted on two groups of AISI 9310 spur gears. Both groups were manufactured with standard ground tooth surfaces, with the second group subjected to an additional shot peening process on the gear tooth flanks.
Townsend, D. P., Zaretsky, E. V.
core   +1 more source

Silicon material and JPL Web Team [PDF]

, 1985
Silicon material activities are described. Topics discussed include: fluidized bed technology, model predictions (reaction kinetics and grid design parameters), seed-particle cleaning procedure, runaway nucleation, thermal analysis of dendritic ribbons ...
Lutwack, R.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Analysis of the DCB test of angle-ply laminates including residual stresses

, 2017
J. De Gracia, A. Boyano, A. Arrese, F. Mujika   +3 more
openalex   +2 more sources

Influencing Factors on Measuring Surface Residual Stress of Steel Bars by X-ray Diffraction Method [PDF]

, 2021
Yiwen Wu, Sijin Li, Zhu Pei, Xiaoyu Wang
openalex   +1 more source