Results 101 to 110 of about 2,222,500 (385)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

A quantum mechanical analysis of the light-harvesting complex 2 from purple photosynthetic bacteria. Insights into the electrostatic effects of transmembrane helices

, 2010
We perform a quantum mechanical study of the peptides that are part of the LH2 complex from Rhodopseudomonas acidophila, a non-sulfur purple bacteria that has the ability of producing chemical energy from photosynthesis.
Bryant, Cogdell, Cogdell, Cogdell, Cramer, Damjanović, Fabio Pichierri, Glaser, He, Herek, Hoff, Hol, Hu, Isaacs, Kjellberg, Klamt, Koepke, Linnanto, Nicholls, Papiz, Pichierri, Pichierri, Pichierri, Pichierri, Prince, Roszak, Scholes, Stewart, Stewart, Stewart, Stewart, Ullmann, van Oijen   +32 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii [PDF]

, 2014
Acinetobacter baumannii is an important human pathogen that can form biofilms and persist under harsh environmental conditions. Biofilm formation and virulence are modulated by blue light, which is thought to be regulated by a BLUF protein, BlsA.
Adelbert Bacher, Agnieszka Gil, Allison Haigney, Andras Lukacs, Barth A., Bitrian M., Boris Illarionov, Brust R., Carlos Simmerling, Cheng-Tsung Lai, Decatur S. M., Gaddy J. A., Giamarellou H., Golic A., Gregory M. Greetham, Grinstead J. S., Haigney A., Haigney A., Hasegawa K., Hasegawa K., Ian P. Clark, Jung A., Kiri Addison, Kondo M., Losi A., Lukacs A., Markus Fischer, Masuda S., Masuda S., Masuda S., McQueary C. N., Michael Towrie, Mussi M. A., Pelton J. T., Peter J. Tonge, Richard Brust, Ryu-Ryun Kim, Shahrier Hossain, Stelling A. L., Stephen R. Meech, Suzuki H., Takahashi R., Wu Q., Yuan H., Yuan H., Yuan H.   +45 more
core   +2 more sources

Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry [PDF]

, 2000
Michael Noble, Sheraz Gul, Chandra S. VERMA, K Brocklehurst   +3 more
openalex   +2 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Molecular Requirements for Ethanol Differential Allosteric Modulation of Ligand-Gated Ion Channels Based on Selective G Beta Gamma Modulation [PDF]

, 2010
It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure.
Aguayo, Luis G, Avila, Ariel, Figueroa, Maximiliano, Guzman, Leonardo, Moraga-Cid, Gustavo, Peoples, Robert W., Yevenes, Gonzalo E   +6 more
core   +1 more source

‘User-friendly’ primary phosphines and an arsine: synthesis and characterization of new air-stable ligands incorporating the ferrocenyl group [PDF]

, 2002
Reaction of FcCH₂CH₂P(O)(OH)₂ or FcCH₂P(O)(OH)(OEt) [Fc=Fe(η⁵-C₅H₄)(η⁵-C₅H₅)] with excess CH₂N₂ followed by reduction with Me₃SiCl–LiAlH₄ gives the air-stable primary phosphines FcCH₂CH₂PH₂ and the previously reported analogue FcCH₂PH₂ in high yields ...
Alley, Steven R., Henderson, William
core   +2 more sources

Electrosynthesis of Artificial Peptides and Nucleosides via the Nitromethane–Lithium Perchlorate Electrolyte System: A Review

ChemElectroChem
Remarkable advances have recently been achieved in the application of electrochemical methodology in synthetic chemistry area. In the past few decades, various oxidative electrochemical reactions have reportedly been enhanced using a nitromethane–lithium
Dr. Kazuhiro Okamoto, Prof. Dr. Kazuhiro Chiba   +1 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source