Results 41 to 50 of about 108,664 (314)

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages

Nature Communications
Plasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination.
Pengdbamba Dieudonné Zongo, Nicolas Cabanel, Guilhem Royer, Florence Depardieu, Alain Hartmann, Thierry Naas, Philippe Glaser, Isabelle Rosinski-Chupin   +7 more
doaj   +1 more source

Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Mycoplasma hyopneumoniae Isolated from Pigs with Enzootic Pneumonia in Australia

Pathogens
Mycoplasma hyopneumoniae, an important cause of enzootic pneumonia in pigs in many countries, has recently been shown to exhibit reduced susceptibility to several antimicrobial classes.
Raziallah Jafari Jozani, Mauida F. Hasoon Al Khallawi, Hanh Thi Hong Nguyen, Majed H. Mohammed, Kiro Petrovski, Yan Ren, Darren Trott, Farhid Hemmatzadeh, Wai Yee Low   +8 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Ecology, alterity and resistance in Sardinia

Social Anthropology, 2001
La question de l'environnement est devenue un enjeu decisif dans la negociation de l'identite culturelle en Europe. Le probleme de la resistance locale a la creation de nouveaux sites de conservation nous entraine a interroger comment la topique de l'alterite culturelle donne forme aux programmes environnementaux des marges rurales de l'Union ...
openaire   +1 more source

Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character

mSystems, 2021
Evolution of multidrug-resistant bacterial pathogens occurs at multiple scales, in the patient, locally in the hospital, or more globally. Some mutations or gene acquisitions, for instance in response to antibiotic treatment, may be restricted to a ...
Nicolas Cabanel, Isabelle Rosinski-Chupin, Adriana Chiarelli, Tatiana Botin, Marta Tato, Rafael Canton, Philippe Glaser   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A multi-species model to assess the effect of refugia on worm control and anthelmintic resistance in sheep grazing systems [PDF]

, 2011
Develop a computer simulation model that uses daily meteorological data and farm management practices to predict populations of Trichostrongylus colubriformis, Haemonchus contortus and Teladorsagia (Ostertagia) circumcincta and the evolution of ...
Barnes, E.H., Tyrrell, K.L., Tyrrell, K. L., Rolfe, P.F., Dobson, R. J., Dobson, R.J., Love, S., Hosking, B. C., Larsen, J. W.A., Bailey, J. N., Larsen, J.W.A., Besier, R.B., Barnes, E. H., Besier, R. B., Hosking, B.C., Rolfe, P. F., Bailey, J.N.   +16 more
core   +2 more sources

Identification of blaESBL- and blaCARBA- Positive Multi-Drug Resistant Mixta calida Isolates from Distinct Human Hosts

International Journal of Medical Microbiology
Objective: This study aimed to investigate the identification of blaCARBA-positive multidrug-resistant Mixta calida isolates from human hosts and to elucidate their genomic determinants in a species-wide context.
Francesca McDonagh, Kate Ryan, Aneta Kovářová, Anna Tumeo, Christina Clarke, Martin Cormican, Georgios Miliotis   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Antimicrobial resistance and the environment : assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing [PDF]

, 2017
A roundtable discussion held at the fourth International Symposium on the Environmental Dimension of Antibiotic Resistance (EDAR4) considered key issues concerning the impact on the environment of antibiotic use in agriculture and aquaculture, and ...
Van den Eede, Chris, Chris Van den Eede, Virta, Marko P J, Miller, Daniel N, Edward Topp, D G Joakim Larsson, Larsson, D. G. Joakim, Topp, Edward, Miller, Daniel N., Larsson, D. G. Joakim,, Virta, Marko P. J., Daniel N Miller, Marko P J Virta   +12 more
core   +1 more source