Results 81 to 90 of about 855,776 (315)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Molecular Mechanisms Underlying Resistance to Bacillus thuringiensis Cry Toxins in Lepidopteran Pests: An Updated Research Perspective

Agronomy
Genetically modified crops that produce insecticidal proteins from Bacillus thuringiensis (Bt) are currently the most efficient and safest method of pest control worldwide.
Deqin Hu, Dongmei Wang, Hongsheng Pan, Xiaoning Liu   +3 more
doaj   +1 more source

Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]

, 2015
The brown rat (Rattus norvegicus) is a relatively recent (
Eleanor P. Jones, Mohd Z.H. Haniza, R. H. Smith (7659080), Jones, Eleanor P., Adams, Sally, Sally Adams, MacNicoll, Alan, Mark S. Lambert, Eamonn B. Mallon, S. Adams (1469704), Mallon, Eamonn B., M. S. Lambert (7659083), Haniza, Mohd Z.H., Alan MacNicoll, Eamonn Bernard Mallon (7607027), Smith, Robert H., Robert H. Smith, E. P. Jones (7659074), M. Z. Haniza (7659071), A. M. MacNicoll (7659077), Lambert, Mark S.   +20 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Inheritance and Fitness Cost of Laboratory-Selected Resistance to Cry1Ab in Hyphantria cunea Drury (Lepidoptera: Arctiidae)

Insects
Transgenic poplars have been used to control quarantine pests worldwide, such as the fall webworm (Hyphantria cunea, FW). However, the studies on the resistance mechanism of FW to Cry toxins are limited.
Laipan Liu, Wenjing Shen, Zhentao Ren, Zhixiang Fang, Li Zhang, Xin Yin, Qi Yu, Biao Liu   +7 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Determination of resistance improving potentials of cotton whitefly Bemisia tabaci (Genn.) (Hemiptera: Aleyrodidae) biotypes against cyantraniliprole

Plant Protection Science
Bemisia tabaci is a significant insect pest that causes extensive agricultural damage. The MEAM1 (Middle East-Asia Minor) and MED (Mediterranean) genetic groups of B. tabaci are the most prevalent cryptic species.
Isse Hassan Ali, Utku Yükselbaba
doaj   +1 more source

Herbicide resistance in weeds [PDF]

, 2017
Resistance at the field level is best considered as 'shades of grey', with a continuum from complete susceptibility through to complete resistance. This poses a considerable challenge in detection and in assessing the severity and impact of resistance ...
Moss, S. R., Stephen Moss
core   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source