Results 121 to 130 of about 86,799,447 (290)

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

open access: yesiMetaMed, EarlyView.
A pan‐cancer atlas deciphers tumor‐induced reprogramming in bone metastases. Malignant evolution toward MYC/proliferation is a hallmark of bone metastases. Niche‐mediated immune dysfunction is characterized by immature pDCs, impaired antigen presentation and phagocytosis in TAMs, and exhausted T cells.
Yitong Pan   +4 more
wiley   +1 more source

The Association between Vitamin D Status and the Impact of Metformin on Hypothalamic–Pituitary–Thyroid Axis Activity in Women with Subclinical Hypothyroidism

open access: yesPharmaceutics
Metformin inhibits enhanced secretion of anterior pituitary hormones. Its impact on prolactin and gonadotropin concentrations is absent in individuals with hypovitaminosis D.
Robert Krysiak   +3 more
doaj   +1 more source

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

The organisational effects of adolescent gonadal hormones on behavioural development in rats [PDF]

open access: yes, 2015
Gonadal steroid hormones play an important role in adolescent neural and behavioural development, causing changes that can be seen throughout life. Endogenous hormones have a direct impact on behaviour in both immediate and permanent ways by acting on ...
Kulbarsh, Kyle D.
core   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó   +3 more
wiley   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo   +10 more
wiley   +1 more source

Personalized multimodal physiological modeling of menstrual cycle dynamics using endocrine, metabolic and wearable signals

open access: yesJournal of Intelligent Medicine, EarlyView.
Abstract Menstrual cycle tracking remains challenged by the limited physiological scope and inconsistent generalizability of existing wearable‐based approaches, which often rely on individual sensing modalities that incompletely capture the complexity of menstrual physiology.
Ejay Nsugbe, Georgianna Lin
wiley   +1 more source

Thyroid Hormone Resistance Syndromes

open access: yes, 2019
Syndromes with impaired sensitivity to thyroid hormone (TH) include three types of resistance to thyroid hormone (RTH) syndromes (RTHβ, RTHα, and nonTR-RTH) and also include patients with defects in TH transport into cells (thyroid hormone cell membrane ...
Refetoff, Samuel   +3 more
core   +1 more source

Application of MR Cytometry in Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparative Study

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MR cytometry imaging is developed to characterize in vivo microstructures. Its clinical value in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer remains unknown. Purpose To implement MR cytometry to predict pCR for breast cancer and compare the performance of different ...
Jie Ding   +10 more
wiley   +1 more source

Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from an Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) expert group

open access: yesJPGN Reports, EarlyView.
Abstract The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with ...
Carlo Agostoni   +46 more
wiley   +1 more source

Home - About - Disclaimer - Privacy